Title :

Anemia in young patients with ischaemic stroke

Author(s) :

Kellert, Lars [Auteur]
Kloss, Manja [Auteur]
Pezzini, Alessandro [Auteur]
Metso, Tiina M. [Auteur]
Metso, Antti J. [Auteur]
Debette, Stéphanie [Auteur]
LEYS, Didier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Caso, Valeria [Auteur]
Thijs, Vincent N. S. [Auteur]
Bersano, Anna [Auteur]
Touze, Emmanuel [Auteur]
Tatlisumak, Turgut [Auteur]
Gensicke, Henrik [Auteur]
Lyrer, Philippe A. [Auteur]
Boesel, J. [Auteur]
Engelter, Stefan T. [Auteur]
Grond-Ginsbach, Caspar [Auteur]

Journal title :

European journal of neurology

Abbreviated title :

Eur. J. Neurol.

Volume number :

22

Pages :

948-953

Publication date :

2015-06-01

ISSN :

1351-5101

English keyword(s) :

anemia
stroke severity
ischaemic stroke
cervical artery dissection

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes ...
Show more >OBJECTIVE: To investigate the association of anemia on admission with ischaemic stroke (IS), stroke severity and early functional outcome in patients with cervical artery dissection (CeAD) or with IS of other causes (non-CeAD-IS patients). METHODS: The study sample comprised all patients from the Cervical Artery Dissection and Ischaemic Stroke Patients (CADISP) study without pre-existing disability and with documentation of stroke severity and hemoglobin (Hb) concentration on admission. Anemia was classified as mild (Hb < 12 g/dl in women and Hb < 13 g/dl in men) or moderate to severe (Hb < 10 g/dl in women and Hb < 11 g/dl in men). Stroke severity on admission was assessed with the National Institutes of Health Stroke Scale (NIHSS). Outcome after 3 months was assessed with the modified Rankin Scale (mRS-3mo). Unfavorable outcome was defined as mRS-3mo ≥ 3. RESULTS: Amongst 1206 study patients (691 CeAD and 515 non-CeAD), 87 (7.2%) had anemia, which was moderate to severe in 18 (1.5%) patients. Anemia was associated with female sex in both study samples, but no further associations with risk factors or comorbidities were observed. In CeAD patients, anemia was associated with occurrence of stroke (P = 0.042). In both study samples, anemic patients had more severe strokes (CeAD, P = 0.023; non-CeAD, P = 0.005). Functional outcome was not associated with anemia in general, but moderate to severe anemia was significantly associated with unfavorable outcome (P = 0.004). CONCLUSIONS: Anemia on admission was associated with stroke in CeAD patients and with more severe strokes in both study samples. Moderate to severe anemia may predict unfavorable outcome.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:28:59Z