Title :

Impact of renal dysfunction on results of transcatheter aortic valve replacement outcomes in a large multicenter cohort

Author(s) :

Codner, Pablo [Auteur]
Levi, Amos [Auteur]
Gargiulo, Giuseppe [Auteur]
Praz, Fabien [Auteur]
Hayashida, Kentaro [Auteur]
Watanabe, Yusuke [Auteur]
Mylotte, Darren [Auteur]
Debry, Nicolas [Auteur]
Barbanti, Marco [Auteur]
Lefevre, Thierry [Auteur]
Modine, Thomas [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Bosmans, Johan [Auteur]
Windecker, Stephan [Auteur]
Barbash, Israel [Auteur]
Sinning, Jan-Malte [Auteur]
Nickenig, Georg [Auteur]
Barsheshet, Alon [Auteur]
Kornowski, Ran [Auteur]

Journal title :

The American journal of cardiology

Abbreviated title :

Am. J. Cardiol.

Volume number :

118

Pages :

1888-1896

Publication date :

2016-12-15

ISSN :

0002-9149

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Patients with advanced chronic renal dysfunction were excluded from randomized trials of transcatheter aortic valve replacement (TAVR). The potential impact of chronic renal disease on TAVR prognosis is not fully understood. ...
Show more >Patients with advanced chronic renal dysfunction were excluded from randomized trials of transcatheter aortic valve replacement (TAVR). The potential impact of chronic renal disease on TAVR prognosis is not fully understood. We aim to evaluate outcomes within a large cohort of patients who underwent TAVR distinguished by renal function. Baseline characteristics, procedural data, and clinical follow-up findings were collected from 10 high-volume TAVR centers in Europe, Israel, and Japan. Data were analyzed according to renal function. Patients (n = 1,204) were divided into 4 groups according to pre-TAVR-estimated glomerular filtration rate (eGFR): group I (eGFR >60), n = 288 (female 45%), group II (eGFR 31 to 60), n = 452 (female 61%), group III (eGFR ≤30), n = 398 (female 61%), and group IV (dialysis), n = 66 (female 31%). Mean Society of Thoracic Surgeons score was higher in patients with lower preprocedural eGFR. All-cause mortality at 1 year was higher in patients with lower eGFR (9.0%, 12.1%, 24.3%, and 24.2% for group I, II, III, and IV, respectively, p <0.001). Multivariate analysis demonstrated that eGFR ≤30, but not eGFR 31 to 60, was associated with increased risk of death (odds ratio 3), bleeding (odds ratio 5.2), and device implantation failure (hazard ratio 2.28). For each 10 ml/min decrease in eGFR, there was an associated relative increase in the risk of death (35%; p <0.001), cardiovascular death (14%; p = 0.018), major bleeding 35% (p <0.001), and transcatheter valve failure (16%; p = 0.007). Renal dysfunction was not associated with stroke or need for pacemaker implantation. In conclusion, among patients who underwent TAVR, baseline renal dysfunction is an important independent predictor of morbidity and mortality.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:29:20Z