Primary progressive aphasia in the network ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Primary progressive aphasia in the network of french alzheimer plan memory centers
Auteur(s) :
Magnin, Eloi [Auteur]
Demonet, Jean-François [Auteur]
Wallon, David [Auteur]
Dumurgier, Julien [Auteur]
Troussiere, Anne-Cecile [Auteur]
Jager, Alain [Auteur]
Duron, Emmanuelle [Auteur]
Gabelle, Audrey [Auteur]
De La Sayette, Vincent [Auteur]
Volpe-Gillot, Lisette [Auteur]
Tio, Gregory [Auteur]
Evain, Sarah [Auteur]
Boutoleau-Bretonniere, Claire [Auteur]
Enderle, Adeline [Auteur]
Mouton-Liger, François [Auteur]
Robert, Philippe-Henri [Auteur]
Hannequin, Didier [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Hugon, Jacques [Auteur]
Paquet, Claire [Auteur]
Demonet, Jean-François [Auteur]
Wallon, David [Auteur]
Dumurgier, Julien [Auteur]
Troussiere, Anne-Cecile [Auteur]
Jager, Alain [Auteur]
Duron, Emmanuelle [Auteur]
Gabelle, Audrey [Auteur]
De La Sayette, Vincent [Auteur]
Volpe-Gillot, Lisette [Auteur]
Tio, Gregory [Auteur]
Evain, Sarah [Auteur]
Boutoleau-Bretonniere, Claire [Auteur]
Enderle, Adeline [Auteur]
Mouton-Liger, François [Auteur]
Robert, Philippe-Henri [Auteur]
Hannequin, Didier [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Hugon, Jacques [Auteur]
Paquet, Claire [Auteur]
Titre de la revue :
Journal of Alzheimer's disease . JAD
Nom court de la revue :
J. Alzheimers Dis.
Numéro :
54
Pagination :
1459-1471
Date de publication :
2016-01-01
ISSN :
1387-2877
Mot(s)-clé(s) en anglais :
primary progressive aphasia
Alzheimer''s disease
gender
cerebrospinal fluid biomarkers
epidemiology
frontotemporal dementia
Alzheimer''s disease
gender
cerebrospinal fluid biomarkers
epidemiology
frontotemporal dementia
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Few demographical data about primary progressive aphasia (PPA) are available, and most knowledge regarding PPA is based on tertiary centers' results.
Our aims were to describe demographical characteristics of the PPA ...
Lire la suite >Few demographical data about primary progressive aphasia (PPA) are available, and most knowledge regarding PPA is based on tertiary centers' results. Our aims were to describe demographical characteristics of the PPA population in a large sample of PPA patients from the network of French Alzheimer plan memory centers (Sample 1), and to describe the stratification of cerebrospinal fluid (CSF) biomarkers in two different samples of PPA patients (Samples 2 and 3). All registered PPA patients in the French Alzheimer's disease (AD) databank (Sample 1: n = 2,035) and a subsample (Sample 2: n = 65) derived from a multicentric prospective cohort with CSF biomarker analysis were analyzed. A multicentric retrospective cohort from language expert tertiary centers (Sample 3: n = 97) with CSF biomarker analysis was added. Sample 3 was added to replicate the CSF results of the Sample 2 and to evaluate repartition of AD pathology in the three variant of PPA according to the latest classification. Non-Fluent/Agrammatic, Logopenic, and Unclassifiable PPA patients (NF/A-Logo-Unclass PPA) were older and more frequent than Semantic PPA patients (2.2 versus 0.8/100,000 inhabitants; p < 0.00001). Male predominance occurred after the age of 80 (p < 0.00001). A higher level of education was observed in the PPA population compared to a typical amnesic AD group. No demographical significant difference between PPA due to AD and not due to AD was observed. The Logopenic variant was most frequent with 85% of AD CSF biomarker profiles (35% in NF/A PPA; 20% in Semantic PPA). PPA occurs also in an elderly population, especially in male patients over 80. CSF biomarkers are useful to stratify PPA. The epidemiology of PPA should be further investigated to confirm gender and cognitive reserve role in PPA to better understand the factors and mechanisms leading to this language-predominant deficit during neurodegenerative diseases.Lire moins >
Lire la suite >Few demographical data about primary progressive aphasia (PPA) are available, and most knowledge regarding PPA is based on tertiary centers' results. Our aims were to describe demographical characteristics of the PPA population in a large sample of PPA patients from the network of French Alzheimer plan memory centers (Sample 1), and to describe the stratification of cerebrospinal fluid (CSF) biomarkers in two different samples of PPA patients (Samples 2 and 3). All registered PPA patients in the French Alzheimer's disease (AD) databank (Sample 1: n = 2,035) and a subsample (Sample 2: n = 65) derived from a multicentric prospective cohort with CSF biomarker analysis were analyzed. A multicentric retrospective cohort from language expert tertiary centers (Sample 3: n = 97) with CSF biomarker analysis was added. Sample 3 was added to replicate the CSF results of the Sample 2 and to evaluate repartition of AD pathology in the three variant of PPA according to the latest classification. Non-Fluent/Agrammatic, Logopenic, and Unclassifiable PPA patients (NF/A-Logo-Unclass PPA) were older and more frequent than Semantic PPA patients (2.2 versus 0.8/100,000 inhabitants; p < 0.00001). Male predominance occurred after the age of 80 (p < 0.00001). A higher level of education was observed in the PPA population compared to a typical amnesic AD group. No demographical significant difference between PPA due to AD and not due to AD was observed. The Logopenic variant was most frequent with 85% of AD CSF biomarker profiles (35% in NF/A PPA; 20% in Semantic PPA). PPA occurs also in an elderly population, especially in male patients over 80. CSF biomarkers are useful to stratify PPA. The epidemiology of PPA should be further investigated to confirm gender and cognitive reserve role in PPA to better understand the factors and mechanisms leading to this language-predominant deficit during neurodegenerative diseases.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Équipe(s) de recherche :
Troubles cognitifs dégénératifs et vasculaires
Date de dépôt :
2019-11-27T14:29:47Z