The role of the melanoma gene mc1r in ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
The role of the melanoma gene mc1r in parkinson disease and rem sleep behavior disorder
Author(s) :
Gan-Or, Ziv [Auteur]
Mohsin, Noreen [Auteur]
Girard, Simon L. [Auteur]
Montplaisir, Jacques Y. [Auteur]
Ambalavanan, Amirthagowri [Auteur]
Strong, Stéphanie [Auteur]
Mallett, Victoria [Auteur]
Laurent, Sandra B. [Auteur]
Bourassa, Cynthia V. [Auteur]
Boivin, Michel [Auteur]
Langlois, Melanie [Auteur]
Arnulf, Isabelle [Auteur]
Hogl, Birgit [Auteur]
Frauscher, Birgit [Auteur]
Meriaux, Christelle [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Desautels, Alex [Auteur]
Gagnon, Jean-François [Auteur]
Postuma, Ronald B. [Auteur]
Dion, Patrick A. [Auteur]
Dauvilliers, Yves [Auteur]
Dupre, Nicolas [Auteur]
Alcalay, Roy N. [Auteur]
Rouleau, Guy A. [Auteur]
Mohsin, Noreen [Auteur]
Girard, Simon L. [Auteur]
Montplaisir, Jacques Y. [Auteur]
Ambalavanan, Amirthagowri [Auteur]
Strong, Stéphanie [Auteur]
Mallett, Victoria [Auteur]
Laurent, Sandra B. [Auteur]
Bourassa, Cynthia V. [Auteur]
Boivin, Michel [Auteur]
Langlois, Melanie [Auteur]
Arnulf, Isabelle [Auteur]
Hogl, Birgit [Auteur]
Frauscher, Birgit [Auteur]
Meriaux, Christelle [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Desautels, Alex [Auteur]
Gagnon, Jean-François [Auteur]
Postuma, Ronald B. [Auteur]
Dion, Patrick A. [Auteur]
Dauvilliers, Yves [Auteur]
Dupre, Nicolas [Auteur]
Alcalay, Roy N. [Auteur]
Rouleau, Guy A. [Auteur]
Journal title :
Neurobiology of aging
Abbreviated title :
Neurobiol. Aging
Volume number :
43
Publication date :
2016-07-01
ISSN :
0197-4580
English keyword(s) :
Melanoma
Parkinson disease
Genetics
MC1R
Parkinson disease
Genetics
MC1R
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior ...
Show more >The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common variants was associated with PD or RBD in the different regression models. In a meta-analysis with fixed-effect model, the p.R160W variant was associated with an increased risk for PD (odds ratio = 1.22, 95% confidence interval = 1.02-1.47, p = 0.03) but with significant heterogeneity (p = 0.048). Removing one study that introduced the heterogeneity resulted in nonsignificant association (odds ratio = 1.11, 95% confidence interval, 0.92-1.35, p = 0.27, heterogeneity p = 0.57). Rare variants had similar frequencies in patients and controls (10.54% and 10.15%, respectively, p = 0.75), and no cumulative effect of carrying more than one MC1R variant was found. The present study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD.Show less >
Show more >The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common variants was associated with PD or RBD in the different regression models. In a meta-analysis with fixed-effect model, the p.R160W variant was associated with an increased risk for PD (odds ratio = 1.22, 95% confidence interval = 1.02-1.47, p = 0.03) but with significant heterogeneity (p = 0.048). Removing one study that introduced the heterogeneity resulted in nonsignificant association (odds ratio = 1.11, 95% confidence interval, 0.92-1.35, p = 0.27, heterogeneity p = 0.57). Rare variants had similar frequencies in patients and controls (10.54% and 10.15%, respectively, p = 0.75), and no cumulative effect of carrying more than one MC1R variant was found. The present study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T14:30:18Z