Relevance of follow-up in patients with ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Relevance of follow-up in patients with core clinical criteria for alzheimer disease and normal csf biomarkers
Author(s) :
Vercruysse, Olivier [Auteur]
Paquet, Claire [Auteur]
Gabelle, Audrey [Auteur]
Delbeuck, Xavier [Auteur]
Blanc, Frederic [Auteur]
Wallon, David [Auteur]
Dumurgier, Julien [Auteur]
Magnin, Eloi [Auteur]
Martinaud, Olivier [Auteur]
Jung, Barbara [Auteur]
Bousiges, Olivier [Auteur]
Lehmann, Sylvain [Auteur]
Delaby, Constance [Auteur]
Quillard-Muraine, Muriel [Auteur]
Peoc'h, Katell [Auteur]
Laplanche, Jean-Louis [Auteur]
Bouaziz-Amar, Elodie [Auteur]
Hannequin, Didier [Auteur]
Sablonniere, Bernard [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition (LilNCog) - U 1172
Buee, Luc [Auteur]
Hugon, Jacques [Auteur]
Schraen, Susanna [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Bombois, Stephanie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Paquet, Claire [Auteur]
Gabelle, Audrey [Auteur]
Delbeuck, Xavier [Auteur]
Blanc, Frederic [Auteur]
Wallon, David [Auteur]
Dumurgier, Julien [Auteur]
Magnin, Eloi [Auteur]
Martinaud, Olivier [Auteur]
Jung, Barbara [Auteur]
Bousiges, Olivier [Auteur]
Lehmann, Sylvain [Auteur]
Delaby, Constance [Auteur]
Quillard-Muraine, Muriel [Auteur]
Peoc'h, Katell [Auteur]
Laplanche, Jean-Louis [Auteur]
Bouaziz-Amar, Elodie [Auteur]
Hannequin, Didier [Auteur]
Sablonniere, Bernard [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition (LilNCog) - U 1172
Buee, Luc [Auteur]
Hugon, Jacques [Auteur]
Schraen, Susanna [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Bombois, Stephanie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Journal title :
Current Alzheimer Research
Abbreviated title :
Curr Alzheimer Res
Publication date :
2018-01-09
ISSN :
1875-5828
English keyword(s) :
cerebrospinal fluid
Alzheimer disease
dementia
mild cognitive impairment
biomarker
depression
frontotemporal dementia
vascular dementia
Alzheimer disease
dementia
mild cognitive impairment
biomarker
depression
frontotemporal dementia
vascular dementia
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Few patients with a normal cerebrospinal fluid (CSF) biomarker profile fulfill the clinical criteria for Alzheimer disease (AD).
The aim of this study was to test the hypothesis of misdiagnoses for these patients.
Patients ...
Show more >Few patients with a normal cerebrospinal fluid (CSF) biomarker profile fulfill the clinical criteria for Alzheimer disease (AD). The aim of this study was to test the hypothesis of misdiagnoses for these patients. Patients from the e-PLM centers fulfilling the core clinical criteria for probable AD dementia or mild cognitive impairment due to AD (AD-MCI), with normal CSF Aβ1-42, T-tau and P-tau biomarkers and clinical follow-up, were included. Clinical and imaging data were reviewed by an independent board, from baseline (visit with clinical evaluation and CSF analysis) to the end of the follow-up, for a final diagnosis. In the e-PLM cohort of 1098 AD patients with CSF analysis, 37 (3.3%) patients (20 with AD dementia core clinical criteria and 17 with AD-MCI core clinical criteria) had normal CSF biomarker profile and a clinical follow-up. All patients presented with episodic memory impairment and 27 (73%) had medial temporal lobe atrophy on MRI-scan. After a median follow-up of 36 months (range 7-74), the final diagnosis was AD MCI or dementia for 9 (24%) patients, and unlikely due to AD for 28 (76%) patients. A misdiagnosis was corrected in 18 (49%) patients (mood disorders, non-AD degenerative dementia, vascular cognitive impairment, alcohol cognitive disorders, temporal epilepsy and hippocampal sclerosis), and 10 (27%) patients had cognitive disorders of undetermined etiology. AD diagnosis (MCI or dementia) with normal CSF biomarkers is a rare condition. A clinical follow- up is particularly recommended to consider an alternative diagnosis.Show less >
Show more >Few patients with a normal cerebrospinal fluid (CSF) biomarker profile fulfill the clinical criteria for Alzheimer disease (AD). The aim of this study was to test the hypothesis of misdiagnoses for these patients. Patients from the e-PLM centers fulfilling the core clinical criteria for probable AD dementia or mild cognitive impairment due to AD (AD-MCI), with normal CSF Aβ1-42, T-tau and P-tau biomarkers and clinical follow-up, were included. Clinical and imaging data were reviewed by an independent board, from baseline (visit with clinical evaluation and CSF analysis) to the end of the follow-up, for a final diagnosis. In the e-PLM cohort of 1098 AD patients with CSF analysis, 37 (3.3%) patients (20 with AD dementia core clinical criteria and 17 with AD-MCI core clinical criteria) had normal CSF biomarker profile and a clinical follow-up. All patients presented with episodic memory impairment and 27 (73%) had medial temporal lobe atrophy on MRI-scan. After a median follow-up of 36 months (range 7-74), the final diagnosis was AD MCI or dementia for 9 (24%) patients, and unlikely due to AD for 28 (76%) patients. A misdiagnosis was corrected in 18 (49%) patients (mood disorders, non-AD degenerative dementia, vascular cognitive impairment, alcohol cognitive disorders, temporal epilepsy and hippocampal sclerosis), and 10 (27%) patients had cognitive disorders of undetermined etiology. AD diagnosis (MCI or dementia) with normal CSF biomarkers is a rare condition. A clinical follow- up is particularly recommended to consider an alternative diagnosis.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Research team(s) :
Alzheimer et Tauopathies
Troubles cognitifs dégénératifs et vasculaires
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T14:30:34Z