Title :

Is associated with lacunar ischemic stroke and deep ich: meta-analyses among 21,500 cases and 40,600 controls

Author(s) :

Rannikmae, Kristiina [Auteur]
Sivakumaran, Vhinoth [Auteur]
Millar, Henry [Auteur]
Malik, Rainer [Auteur]
Anderson, Christopher D. [Auteur]
Chong, Mike [Auteur]
Dave, Tushar [Auteur]
Falcone, Guido J. [Auteur]
Fernandez-Cadenas, Israel [Auteur]
Jimenez-Conde, Jordi [Auteur]
Lindgren, Arne G. [Auteur]
Montaner, Joan [Auteur]
O''donnell, Martin J. [Auteur]
Pare, Guillaume [Auteur]
Radmanesh, Farid [Auteur]
Rost, Natalia S. [Auteur]
Slowik, Agnieszka [Auteur]
Soderholm, Martin [Auteur]
Traylor, Matthew [Auteur]
Pulit, Sara L. [Auteur]
Seshadri, Sudha [Auteur]
Worrall, Bradford B. [Auteur]
Woo, Daniel [Auteur]
Markus, Hugh S. [Auteur]
Mitchell, Braxton D. [Auteur]
Dichgans, Martin [Auteur]
Rosand, Jonathan [Auteur]
Sudlow, Cathie L. M. [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

89

Pages :

1829-1839

Publication date :

2017-10-24

ISSN :

1526-632X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. METHODS: We meta-analyzed genotype data from individuals of European ancestry to ...
Show more >OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. METHODS: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (COL4A1COL4A2NOTCH3HTRA1TREX1CECR1 RESULTS: A locus in COL4A2p-4p-8p-5HTRA1p-4p-4COL4A2HTRA1 CONCLUSIONS: These results provide evidence of shared genetic determinants and suggest common pathophysiologic mechanisms of distinct ischemic and hemorrhagic cerebral SVD stroke phenotypes, offering new insights into the causal mechanisms of cerebral SVD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:31:22Z