Title :

Surgery in reference centers improves survival of sarcoma patients: a nationwide study

Author(s) :

Blay, Jean-Yves [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Honore, Charles [Auteur]
Institut Gustave Roussy [IGR]
Stoeckle, Eberhard [Auteur]

Meeus, Pierre [Auteur]
Centre Léon Bérard [Lyon]
Jafari, M. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gouin, François [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Anract, P. [Auteur]
Hôpital Cochin [AP-HP]
Ferron, G. [Auteur]
Institut Claudius Regaud [ICR]
Rochwerger, A. [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Ropars, M. [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Carrere, S. [Auteur]
Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM]
Marchal, F. [Auteur]
Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] [UNICANCER/ICL]
Sirveaux, F. [Auteur]
Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] [UNICANCER/ICL]
Di Marco, A. [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Le Nail, L R. [Auteur]
CHU Trousseau [Tours]
Guiramand, J. [Auteur]
Institut Paoli-Calmettes [IPC]
Vaz, G. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Machiavello, J-C [Auteur]

Marco, O. [Auteur]

Causeret, S. [Auteur]
Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] [UNICANCER/CRLCC-CGFL]
Gimbergues, P. [Auteur]
Centre Jean Perrin [Clermont-Ferrand] [UNICANCER/CJP]
Fiorenza, F. [Auteur]
Service d'Oncologie médicale [CHU Limoges]
Chaigneau, Loic [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Guillemin, Francis [Auteur]
CRLCC Jean Godinot
Guilloit, J-M [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Dujardin, F. [Auteur]
Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel]
Spano, J-P [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Ruzic, J-C [Auteur]
Centre Hospitalier Universitaire de La Réunion [CHU La Réunion]
Michot, A. [Auteur]
Institut Gustave Roussy [IGR]
Soibinet, P. [Auteur]
CRLCC Jean Godinot
Bompas, Emmanuelle [Auteur]

Chevreau, Christine [Auteur]

Duffaud, Florence [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Rios, Maria [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Perrin, Christophe [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Firmin, N. [Auteur]
Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM]
Bertucci, François [Auteur]
Institut Paoli-Calmettes [IPC]
Le Pechoux, Cécile [Auteur]
Institut Gustave Roussy [IGR]
Le Loarer, François [Auteur]
Institut Gustave Roussy [IGR]
Collard, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Karanian-Philippe, M. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Brahmi, M. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Dufresne, A. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Dupre, A. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Ducimetiere, Françoise [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Giraud, Antoine [Auteur]
Hôpital Cochin [AP-HP]
Perol, David [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Toulmonde, Maud [Auteur]

Ray-Coquard, Isabelle [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Italiano, Antoine [Auteur]

Le Cesne, Axel [Auteur]
Institut Gustave Roussy [IGR]
Penel, Nicolas [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Bonvalot, Sylvie [Auteur]
Institut Curie [Paris]
jafari [Auteur]

Journal title :

Annals of oncology . official journal of the European Society for Medical Oncology

Abbreviated title :

Ann. Oncol.

Volume number :

30

Pages :

1143-1153

Publication date :

2019-06-05

ISSN :

1569-8041

Other identifier :

PMC6683855

English keyword(s) :

sarcoma
resection
surgery
relapse
survival
reference center

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background NETSARC (netsarc.org) is a network of 26 sarcoma reference centers with specialized multidisciplinary tumor boards (MDTB) aiming to improve the outcome of sarcoma patients. Since 2010, presentation to an MDTB ...
Show more >Background NETSARC (netsarc.org) is a network of 26 sarcoma reference centers with specialized multidisciplinary tumor boards (MDTB) aiming to improve the outcome of sarcoma patients. Since 2010, presentation to an MDTB and expert pathological review are mandatory for sarcoma patients nationwide. In the present work, the impact of surgery in a reference center on the survival of sarcoma patients investigated using this national NETSARC registry. Patients and methods Patients’ characteristics and follow-up are prospectively collected and data monitored. Descriptive, uni- and multivariate analysis of prognostic factors were conducted in the entire series (N = 35 784) and in the subgroup of incident patient population (N = 29 497). Results Among the 35 784 patients, 155 different histological subtypes were reported. 4310 (11.6%) patients were metastatic at diagnosis. Previous cancer, previous radiotherapy, neurofibromatosis type 1 (NF1), and Li–Fraumeni syndrome were reported in 12.5%, 3.6%, 0.7%, and 0.1% of patients respectively. Among the 29 497 incident patients, 25 851 (87.6%) patients had surgical removal of the sarcoma, including 9949 (33.7%) operated in a NETSARC center. Location, grade, age, size, depth, histotypes, gender, NF1, and surgery outside a NETSARC center all correlated to overall survival (OS), local relapse free survival (LRFS), and event-free survival (EFS) in the incident patient population. NF1 history was one of the strongest adverse prognostic factors for LRFS, EFS, and OS. Presentation to an MDTB was associated with an improved LRFS and EFS, but was an adverse prognostic factor for OS if surgery was not carried out in a reference center. In multivariate analysis, surgery in a NETSARC center was positively correlated with LRFS, EFS, and OS [P < 0.001 for all, with a hazard ratio of 0.681 (95% CI 0.618–0.749) for OS]. Conclusion This nationwide registry of sarcoma patients shows that surgical treatment in a reference center reduces the risk of relapse and death.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T16:50:58Z
2020-06-03T08:47:54Z