Titre :

Abstention or intervention for isolated hypotension in the first 3?days of life in extremely preterm infants: association with short-term outcomes in the epipage 2 cohort study

Auteur(s) :

Durrmeyer, Xavier [Auteur]
Marchand-Martin, Laetitia [Auteur]
Porcher, Raphael [Auteur]
Gascoin, Geraldine [Auteur]
Roze, Jean-Christophe [Auteur]
Storme, Laurent [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489
Favrais, Geraldine [Auteur]
Ancel, Pierre-Yves [Auteur]
Cambonie, Gilles [Auteur]

Titre de la revue :

Archives of disease in childhood. Fetal and neonatal edition

Nom court de la revue :

Arch. Dis. Child. Fetal Neonatal Ed.

Numéro :

102

Pagination :

490-496

Date de publication :

2017-11-01

ISSN :

1468-2052

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: To compare outcomes at hospital discharge for preterm infants born before 29 weeks of gestation who had at least one episode of isolated hypotension during their first 72 hours of life for which they did or did ...
Lire la suite >OBJECTIVE: To compare outcomes at hospital discharge for preterm infants born before 29 weeks of gestation who had at least one episode of isolated hypotension during their first 72 hours of life for which they did or did not receive antihypotensive treatment. METHODS: Etude Epidémiologique sur les Petits Ages Gestationnels 2 (EPIPAGE 2) French national prospective population-based cohort study in 2011. METHODS: 60 neonatal intensive care units. METHODS: All infants with a minimum mean arterial blood pressure less than gestational age (in weeks) (minMAP<GA) within 72 hours of birth. Infants whose reason for receiving antihypotensive treatments was isolated hypotension only were compared with untreated hypotensive infants by propensity score matching. METHODS: Fluid bolus and/or inotropes and/or corticosteroids. The primary outcome was survival at hospital discharge without major morbidity, defined as any of necrotising enterocolitis, severe cerebral abnormalities, severe bronchopulmonary dysplasia or severe retinopathy of prematurity. RESULTS: Among the 1532 infants with available data, 662 had a minMAP<GA; 206 were treated for unknown or other reasons than isolated hypotension, 131 were treated for isolated hypotension only and 325 were untreated; 119 infants from each of these last two groups were matched. Treated infants had a significantly higher survival rate without major morbidity (61.3% vs 48.7%; OR, 1.67, 95% CI 1.00 to 2.78, p=0.049) and a lower rate of severe cerebral abnormalities (10.1% vs 26.5%, p=0.002). CONCLUSIONS: In this population, antihypotensive treatment was associated with improved short-term outcomes. Therapeutic abstention should be cautiously considered for early isolated hypotension in extremely premature infants.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

• Environnement Périnatal et Santé - ULR 4489
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-12-09T16:54:47Z