Estimated risk of radiation-induced cancer from paediatric chest ct: two-year cohort study

Niemann, Tilo; Colas, Lucie; Roser, Hans W.; Santangelo, Teresa; Faivre, Jean-Baptiste; Remy, Jacques; Remy, Martine; Bremerich, Jens

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1007/s00247-014-3178-7

PMID :

25274469

Permalink :

http://hdl.handle.net/20.500.12210/17107

Title :

Estimated risk of radiation-induced cancer from paediatric chest ct: two-year cohort study

Author(s) :

Niemann, Tilo [Auteur]
Colas, Lucie [Auteur]
Roser, Hans W. [Auteur]
Santangelo, Teresa [Auteur]
Faivre, Jean-Baptiste [Auteur]
Remy, Jacques [Auteur]
Remy, Martine [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Bremerich, Jens [Auteur]

Journal title :

Pediatric radiology

Abbreviated title :

Pediatr. Radiol.

Volume number :

Pages :

329-336

Publication date :

2015-03-01

ISSN :

0301-0449

English keyword(s) :

Epidemiology
Risk assessment
Computed tomography
Child

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: The increasing absolute number of paediatric CT scans raises concern about the safety and efficacy and the effects of consecutive diagnostic ionising radiation. OBJECTIVE: To demonstrate a method to evaluate ...
Show more >BACKGROUND: The increasing absolute number of paediatric CT scans raises concern about the safety and efficacy and the effects of consecutive diagnostic ionising radiation. OBJECTIVE: To demonstrate a method to evaluate the lifetime attributable risk of cancer incidence/mortality due to a single low-dose helical chest CT in a two-year patient cohort. METHODS: A two-year cohort of 522 paediatric helical chest CT scans acquired using a dedicated low-dose protocol were analysed retrospectively. Patient-specific estimations of radiation doses were modelled using three different mathematical phantoms. Per-organ attributable cancer risk was then estimated using epidemiological models. Additional comparison was provided for naturally occurring risks. RESULTS: Total lifetime attributable risk of cancer incidence remains low for all age and sex categories, being highest in female neonates (0.34%). Summation of all cancer sites analysed raised the relative lifetime attributable risk of organ cancer incidence up to 3.6% in female neonates and 2.1% in male neonates. CONCLUSIONS: Using dedicated scan protocols, total lifetime attributable risk of cancer incidence and mortality for chest CT is estimated low for paediatric chest CT, being highest for female neonates.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Université de Lille

Collections :

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-12-09T18:15:15Z

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