Prediction of local and metastatic recurrence ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Prediction of local and metastatic recurrence in solitary fibrous tumor: construction of a risk calculator in a multicenter cohort from the french sarcoma group (fsg) database
Auteur(s) :
Salas, Sébastien [Auteur]
Resseguier, N. [Auteur]
Blay, Jean-Yves [Auteur]
Le Cesne, Axel [Auteur]
Italiano, Antoine [Auteur]
Chevreau, Christine [Auteur]
Rosset, P. [Auteur]
Isambert, Nicolas [Auteur]
Soulie, Patrick [Auteur]
Cupissol, Didier [Auteur]
Delcambre, Corinne [Auteur]
Bay, Jacques-Olivier [Auteur]
Dubray-Longeras, Pascale [Auteur]
Krengli, M. [Auteur]
De Bari, B. [Auteur]
Villa, S. [Auteur]
Kaanders, J H A M. [Auteur]
Torrente, S. [Auteur]
Pasquier, David [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Thariat, J. O. [Auteur]
Myroslav, L. [Auteur]
Sole, C V. [Auteur]
Dincbas, H F. [Auteur]
Habboush, J Y. [Auteur]
Zilli, T. [Auteur]
Dragan, T. [Auteur]
Khan R, K. [Auteur]
Ugurluer, G. [Auteur]
Cena, T. [Auteur]
Duffaud, Florence [Auteur]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Bertucci, François [Auteur]
Ranchere-Vince, Dominique [Auteur]
Terrier, Philippe [Auteur]
Bonvalot, Sylvie [Auteur]
Macagno, Nicolas [Auteur]
Lemoine, C. [Auteur]
Lae, Marick [Auteur]
Coindre, Jean-Michel [Auteur]
Bouvier, Corinne [Auteur]
Resseguier, N. [Auteur]
Blay, Jean-Yves [Auteur]
Le Cesne, Axel [Auteur]
Italiano, Antoine [Auteur]
Chevreau, Christine [Auteur]
Rosset, P. [Auteur]
Isambert, Nicolas [Auteur]
Soulie, Patrick [Auteur]
Cupissol, Didier [Auteur]
Delcambre, Corinne [Auteur]
Bay, Jacques-Olivier [Auteur]
Dubray-Longeras, Pascale [Auteur]
Krengli, M. [Auteur]
De Bari, B. [Auteur]
Villa, S. [Auteur]
Kaanders, J H A M. [Auteur]
Torrente, S. [Auteur]
Pasquier, David [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Thariat, J. O. [Auteur]
Myroslav, L. [Auteur]
Sole, C V. [Auteur]
Dincbas, H F. [Auteur]
Habboush, J Y. [Auteur]
Zilli, T. [Auteur]
Dragan, T. [Auteur]
Khan R, K. [Auteur]
Ugurluer, G. [Auteur]
Cena, T. [Auteur]
Duffaud, Florence [Auteur]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Bertucci, François [Auteur]
Ranchere-Vince, Dominique [Auteur]
Terrier, Philippe [Auteur]
Bonvalot, Sylvie [Auteur]
Macagno, Nicolas [Auteur]
Lemoine, C. [Auteur]
Lae, Marick [Auteur]
Coindre, Jean-Michel [Auteur]
Bouvier, Corinne [Auteur]
Titre de la revue :
Annals of oncology . official journal of the European Society for Medical Oncology
Nom court de la revue :
Ann. Oncol.
Numéro :
28
Pagination :
1979-1987
Date de publication :
2017-08-01
ISSN :
0923-7534
Mot(s)-clé(s) en anglais :
prognostic factors
competing risks
risk calculator
solitary fibrous tumor
competing risks
risk calculator
solitary fibrous tumor
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Solitary fibrous tumors (SFT) are rare unusual ubiquitous soft tissue tumors that are presumed to be of fibroblastic differentiation. At present, the challenge is to establish accurate prognostic factors.
A total of 214 ...
Lire la suite >Solitary fibrous tumors (SFT) are rare unusual ubiquitous soft tissue tumors that are presumed to be of fibroblastic differentiation. At present, the challenge is to establish accurate prognostic factors. A total of 214 consecutive patients with SFT diagnosed in 24 participating cancer centers were entered into the European database (www.conticabase.org) to perform univariate and multivariate analysis for overall survival (OS), local recurrence incidence (LRI) and metastatic recurrence incidence (MRI) by taking competing risks into account. A prognostic model was constructed for LRI and MRI. Internal and external validations of the prognostic models were carried out. An individual risk calculator was carried out to quantify the risk of both local and metastatic recurrence. We restricted our analysis to 162 patients with local disease. Twenty patients (12.3%) were deceased at the time of analysis and the median OS was not reached. The LRI rates at 10 and 20 years were 19.2% and 38.6%, respectively. The MRI rates at 10 and 20 years were 31.4% and 49.8%, respectively. Multivariate analysis retained age and mitotic count tended to significance for predicting OS. The factors influencing LRI were viscera localization, radiotherapy and age. Mitotic count, tumor localization other than limb and age had independent values for MRI. Three prognostic groups for OS were defined based on the number of unfavorable prognostic factors and calculations were carried out to predict the risk of local and metastatic recurrence for individual patients. LRI and MRI rates increased between 10 and 20 years so relapses were delayed, suggesting that long-term monitoring is useful. This study also shows that different prognostic SFT sub-groups could benefit from different therapeutic strategies and that use of a survival calculator could become standard practice in SFTs to individualize treatment based on the clinical situation.Lire moins >
Lire la suite >Solitary fibrous tumors (SFT) are rare unusual ubiquitous soft tissue tumors that are presumed to be of fibroblastic differentiation. At present, the challenge is to establish accurate prognostic factors. A total of 214 consecutive patients with SFT diagnosed in 24 participating cancer centers were entered into the European database (www.conticabase.org) to perform univariate and multivariate analysis for overall survival (OS), local recurrence incidence (LRI) and metastatic recurrence incidence (MRI) by taking competing risks into account. A prognostic model was constructed for LRI and MRI. Internal and external validations of the prognostic models were carried out. An individual risk calculator was carried out to quantify the risk of both local and metastatic recurrence. We restricted our analysis to 162 patients with local disease. Twenty patients (12.3%) were deceased at the time of analysis and the median OS was not reached. The LRI rates at 10 and 20 years were 19.2% and 38.6%, respectively. The MRI rates at 10 and 20 years were 31.4% and 49.8%, respectively. Multivariate analysis retained age and mitotic count tended to significance for predicting OS. The factors influencing LRI were viscera localization, radiotherapy and age. Mitotic count, tumor localization other than limb and age had independent values for MRI. Three prognostic groups for OS were defined based on the number of unfavorable prognostic factors and calculations were carried out to predict the risk of local and metastatic recurrence for individual patients. LRI and MRI rates increased between 10 and 20 years so relapses were delayed, suggesting that long-term monitoring is useful. This study also shows that different prognostic SFT sub-groups could benefit from different therapeutic strategies and that use of a survival calculator could become standard practice in SFTs to individualize treatment based on the clinical situation.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Université de Lille
Université de Lille
Date de dépôt :
2019-12-09T18:17:00Z
2021-05-19T09:20:19Z
2021-05-19T10:08:59Z
2021-05-19T09:20:19Z
2021-05-19T10:08:59Z