Is bone analysis with mu ct useful for short postmortem interval estimation?

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1007/s00414-017-1696-1

PMID :

URL permanente :

http://hdl.handle.net/20.500.12210/17267

Titre :

Is bone analysis with mu ct useful for short postmortem interval estimation?

Auteur(s) :

Le Garff, Erwan [Auteur]

239526|||Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A] (VALID)
Mesli, Vadim [Auteur]

Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A]
Marchand, Elodie [Auteur]
Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A]
Behal, Helene [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Demondion, Xavier [Auteur]

239526|||Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A] (VALID)
Becart, Anne [Auteur]

Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A]
Hedouin, Valery [Auteur]

239526|||Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A] (VALID)

Titre de la revue :

International journal of legal medicine

Nom court de la revue :

Int. J. Legal Med.

Numéro :

132

Pagination :

269-277

Éditeur :

Springer Link

Date de publication :

2018-01-01

ISSN :

0937-9827

Mot(s)-clé(s) en anglais :

Forensic science
Taphonomy
Micro-CT
Postmortem interval
Forensic anthropology

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The evaluation of the postmortem interval (PMI) is an important consideration in forensic medicine. The time between death and the discovery thereof is extremely important, not only in terms of the legal process, but also ...
Lire la suite >The evaluation of the postmortem interval (PMI) is an important consideration in forensic medicine. The time between death and the discovery thereof is extremely important, not only in terms of the legal process, but also for the course of the investigation. At the time of the discovery of human bones, the evaluation of the PMI is extremely difficult. To date, there is no really effective tool for this evaluation. The objective of our study is to characterize the architectural modifications of human bones using micro-tomography (μCT) in the postmortem period. Ten bone samples were extracted from a single fresh human cranial vault (no freezing, no embalming) from a body donation. The samples were conserved in a controlled environment (a laboratory hood at 20 °C with 60% humidity) for 10 weeks. Every 2 weeks after the death and the sample extraction from the vault, the samples were analyzed with μCT (resolution 10 μm, Bruker HR1172 ®). The 3D analysis focused on general 3D data related to the trabeculae: the total volume (TV), the bone volume (BV), and the bone surface (BS), as well as specific trabeculae data; namely: the number of trabeculae (TbN), trabecular thickness (TbTh), the average distance between the trabeculae (TbSp), and the trabecular pattern factor (TbPf). Each sample was observed separately and compared to itself over time; no comparisons among samples were made. We used a linear mixed model for repeated measures (an unstructured covariance pattern model) and post hoc comparisons between each consecutive time using linear contrast with an SAS software package, release 9.3 (SAS Institute, Cary, NC). We showed a statistical difference for BS/BV (p = 0.046) over time, with a significant decrease during the first 2 weeks (p = 0.003; mean decrease, - 0.99, 95% CI [- 1.61; - 0.36]), while TbSp (p < 0.0001) showed a significant increase during the first 2 weeks (p < 0.0001; mean increase, 0.022, 95% CI, [- 0.016; - 0.028]).Our study highlighted architectural trabecular modifications on postmortem bones using the μCT. These modifications occurred at an early stage, during the first 2 weeks of conservation. Complementary work will need to be performed to allow for better understanding of the biological phenomena observed and to create databases of osseous taphonomy, starting with various individuals, mediums of conservation, types of bone, and with varying techniques for analysis.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Université de Lille

Collections :

Date de dépôt :

2019-12-09T18:17:44Z
2024-03-27T10:15:47Z

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