Title :

A novel microct method for bone and marrow adipose tissue alignment identifies key differences between mandible and tibia in rats

Author(s) :

Coutel, Xavier [Auteur]
Physiopathologie des Maladies Osseuses Inflammatoires (PMOI) - EA 4490
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Olejnik, Cecile [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Physiopathologie des Maladies Osseuses Inflammatoires (PMOI) - ULR 4490
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Marchandise, Pierre [Auteur]
Unité de Taphonomie Médico-Légale (UTML) - ULR 7367
Delattre, Jérôme [Auteur]
Physiopathologie des Maladies Osseuses Inflammatoires (PMOI) - ULR 4490
Behal, Helene [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Kerckhofs, Greet [Auteur]

Penel, Guillaume [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]

Journal title :

Calcified tissue international

Abbreviated title :

Calcif. Tissue Int.

Volume number :

103

Pages :

189-197

Publication date :

2018-01-30

ISSN :

1432-0827

English keyword(s) :

Micro-computed tomography imaging
Bone structure
Osmium staining
Adipocytes
Jaw bone
Rats

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Bone homeostasis is influenced by the bone marrow adipose tissue (BMAT). BMAT distribution varies from one anatomical location in the skeleton to another. We developed an advanced microfocus computed tomography imaging and ...
Show more >Bone homeostasis is influenced by the bone marrow adipose tissue (BMAT). BMAT distribution varies from one anatomical location in the skeleton to another. We developed an advanced microfocus computed tomography imaging and analysis protocol that allows accurate alignment of both the BMAT distribution and bone micro-architecture as well as calculation of the distance of the BMAT adipocytes from the bone surface. Using this protocol, we detected a different spatial BMAT distribution between the rat tibia and mandible: in the proximal metaphysis of the tibia a large amount of BMAT (~ 20% of the total BMAT) was located close to the bone surface (< 20 µm), whereas in the alveolar ridge ~ 30% of the total BMAT was located between 40 and 60 µm from the bone surface. In the alveolar ridge of rats, the trabecular bone volume was 48.3% higher compared to the proximal metaphysis of the tibia (p < 0.0001) and the percentage of adiposity determined to the relative marrow volume was lower (1.5%) compared to the proximal metaphysis of the tibia (9%, p = 0.0002). Interestingly, in the tibia a negative correlation was found between the percentage of adiposity in the total volume and the trabecular thickness (r =- 0.74, p = 0.037). The present study highlights that in comparison to tibial proximal metaphysis, the mandibular bone exhibits a massive trabecular network and a low BMAT content with almost no contact with the bone surface. These findings are of great interest because of the importance of the fat-bone interaction and its potential relevance to several resorptive bone diseases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Univ. Artois
Univ. Littoral Côte d’Opale
Université de Lille

Collections :

• Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Submission date :

2019-12-09T18:18:44Z
2021-11-18T09:39:07Z