Non-islet-cell tumour hypoglycaemia (NICTH): ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Non-islet-cell tumour hypoglycaemia (NICTH): About a series of 6 cases
Author(s) :
Jannin, Arnaud [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Stephanie, Espiard [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Benomar, Kanza [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Do Cao, Christine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Mycinski, Benedicte [Auteur]
Centre Hospitalier de Calais
Porte, Henri [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Thérapies Lasers Assistées par l’Image pour l’Oncologie (ONCO-THAI) - U1189
D''herbomez, Michele [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Vantyghem, Marie-Christine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Stephanie, Espiard [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Benomar, Kanza [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Do Cao, Christine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Mycinski, Benedicte [Auteur]
Centre Hospitalier de Calais
Porte, Henri [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Thérapies Lasers Assistées par l’Image pour l’Oncologie (ONCO-THAI) - U1189
D''herbomez, Michele [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Penel, Nicolas [Auteur]
![refId](/themes/Mirage2//images/idref.png)
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Vantyghem, Marie-Christine [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Journal title :
Annales d'endocrinologie
Abbreviated title :
Ann. Endocrinol. (Paris)
Volume number :
80
Pages :
21-25
Publisher :
Elsevier
Publication date :
2018-03-16
ISSN :
2213-3941
English keyword(s) :
Hypoglycaemia
IGF-2
NICTH
Paraneoplastic syndrome
Hypoinsulinism
IGF-2
NICTH
Paraneoplastic syndrome
Hypoinsulinism
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic ...
Show more >The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic secretion of IGF-2 or its related substances. RESULTS: Three of these 6 patients (50%), aged over 69 years, including 2 with acromegaloid phenotype, presented with a pleural solitary fibrous tumor (SFT), with median diameter 20 cm (interquartile range, 12.5-20.5) with a low median SUV (3.3 g/mL (QR, 2-7.5)) on 18F-FDG PET. The other 3 patients presented respectively neuroendocrine carcinoma (NEC) of the palate (70-year-old woman), retroperitoneal myxofibrosarcoma (66-year-old man) and meningeal hemangiopericytoma (36-year-old woman). All 3 were inoperable and did not respond to any therapy other than glucose solution. Corticosteroid therapy was effective in the 3 SFTs and the NEC. One of the SFTs recurred 10 years later with asymptomatic hypoglycemia, which resolved after reintervention. Median (IQR) blood glucose levels of the 6 patients was 0.4g/L (QR, 0.31-0.41), with hypoinsulinemia at 0.7mIU/L (QR 0.7-2.0), undetectable GH, low IGF-1, normal IGF-2 level in 5/6 cases, a high IGF-2:IGF-1 ratio at 26.9 (QR, 20.8-37.8), hypokalemia and hypomagnesemia. CONCLUSION: NICTH is a rare syndrome, which should be considered in the presence of hypoinsulinemic hypoglycemia with low GH and IGF-1, and a IGF-2:IGF-1 ratio>10. Corticosteroid therapy was effective in elderly subjects, particularly with solitary fibrous tumor, which was generally operable. Hemangiopericytoma and myxofibrosarcoma had poor prognosis in younger patients.Show less >
Show more >The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic secretion of IGF-2 or its related substances. RESULTS: Three of these 6 patients (50%), aged over 69 years, including 2 with acromegaloid phenotype, presented with a pleural solitary fibrous tumor (SFT), with median diameter 20 cm (interquartile range, 12.5-20.5) with a low median SUV (3.3 g/mL (QR, 2-7.5)) on 18F-FDG PET. The other 3 patients presented respectively neuroendocrine carcinoma (NEC) of the palate (70-year-old woman), retroperitoneal myxofibrosarcoma (66-year-old man) and meningeal hemangiopericytoma (36-year-old woman). All 3 were inoperable and did not respond to any therapy other than glucose solution. Corticosteroid therapy was effective in the 3 SFTs and the NEC. One of the SFTs recurred 10 years later with asymptomatic hypoglycemia, which resolved after reintervention. Median (IQR) blood glucose levels of the 6 patients was 0.4g/L (QR, 0.31-0.41), with hypoinsulinemia at 0.7mIU/L (QR 0.7-2.0), undetectable GH, low IGF-1, normal IGF-2 level in 5/6 cases, a high IGF-2:IGF-1 ratio at 26.9 (QR, 20.8-37.8), hypokalemia and hypomagnesemia. CONCLUSION: NICTH is a rare syndrome, which should be considered in the presence of hypoinsulinemic hypoglycemia with low GH and IGF-1, and a IGF-2:IGF-1 ratio>10. Corticosteroid therapy was effective in elderly subjects, particularly with solitary fibrous tumor, which was generally operable. Hemangiopericytoma and myxofibrosarcoma had poor prognosis in younger patients.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Université de Lille
Université de Lille
Submission date :
2019-12-09T18:20:44Z
2021-06-25T08:30:45Z
2024-04-10T09:20:32Z
2021-06-25T08:30:45Z
2024-04-10T09:20:32Z