4-Aminoquinoline-β-Lactam Conjugates: ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
4-Aminoquinoline-β-Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation
Auteur(s) :
Raj, Raghu [Auteur]
Biot, Christophe [Auteur]
Carrère-Kremer, Séverine [Auteur]
Kremer, Laurent [Auteur]
Guerardel, Yann [Auteur]
Gut, Jiri [Auteur]
Rosenthal, Philip J [Auteur]
Kumar, Vipan [Auteur]
Biot, Christophe [Auteur]
Carrère-Kremer, Séverine [Auteur]
Kremer, Laurent [Auteur]
Guerardel, Yann [Auteur]
Gut, Jiri [Auteur]
Rosenthal, Philip J [Auteur]
Kumar, Vipan [Auteur]
Titre de la revue :
Chemical Biology & Drug Design
Nom court de la revue :
Chem Biol Drug Des
Numéro :
83
Pagination :
191-197
Date de publication :
2014-02
ISSN :
1747-0285
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
A library of quinoline-β-lactam-based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N-1 ...
Lire la suite >A library of quinoline-β-lactam-based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N-1 substituent of the β-lactam ring as well as the length of alkyl chain. Most of the compounds are not as efficient as chloroquine in inhibiting the culture growth of Plasmodium falciparum W2 strain. Nevertheless, the synthesized hybrids showed better antitubercular activities (up to five times) compared with cephalexin (up to three times) and ethionamide.Lire moins >
Lire la suite >A library of quinoline-β-lactam-based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N-1 substituent of the β-lactam ring as well as the length of alkyl chain. Most of the compounds are not as efficient as chloroquine in inhibiting the culture growth of Plasmodium falciparum W2 strain. Nevertheless, the synthesized hybrids showed better antitubercular activities (up to five times) compared with cephalexin (up to three times) and ethionamide.Lire moins >
Langue :
Anglais
Établissement(s) :
CNRS
Université de Lille
Université de Lille
Équipe(s) de recherche :
Glycobiologie structurale des interactions hôtes-pathogènes
Date de dépôt :
2020-02-12T15:11:08Z