Flexible Nanoholey Patches for Antibiotic-Free ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
Flexible Nanoholey Patches for Antibiotic-Free Treatments of Skin Infections
Author(s) :
Li, Chengnan [Auteur]
Ye, Ran [Auteur]
Bouckaert, Julie [Auteur]
Zurutuza, Amaia [Auteur]
Drider, Djamel [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Dumych, Tetiana [Auteur]
Paryzhak, Solomiya [Auteur]
Vovk, Volodymyr [Auteur]
Bilyy, Rostyslav [Auteur]
Melinte, Sorin [Auteur]
Li, Musen [Auteur]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Ye, Ran [Auteur]
Bouckaert, Julie [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Zurutuza, Amaia [Auteur]
Drider, Djamel [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Dumych, Tetiana [Auteur]
Paryzhak, Solomiya [Auteur]
Vovk, Volodymyr [Auteur]
Bilyy, Rostyslav [Auteur]
Melinte, Sorin [Auteur]
Li, Musen [Auteur]
Boukherroub, Rabah [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Journal title :
ACS Applied Materials & Interfaces
Abbreviated title :
ACS Appl Mater Interfaces
Volume number :
9
Pages :
36665-36674
Publication date :
2017-10-25
ISSN :
1944-8252
English keyword(s) :
polyimide
reduced graphene oxide
wound infection
photothermal therapy
bacteria ablation
in vivo treatment
gold nanoholes
reduced graphene oxide
wound infection
photothermal therapy
bacteria ablation
in vivo treatment
gold nanoholes
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic ...
Show more >Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic penetration to bacterial infection sites as well as the development of antibiotic-resistant pathogens. In the case of skin infection, the wound is covered by exudate, making it impermeable to topical antibiotics. The development of a flexible patch allowing a rapid and highly efficient treatment of subcutaneous wound infections via photothermal irradiation is presented here. The skin patch combines the near-infrared photothermal properties of a gold nanohole array formed by self-assembly of colloidal structures on flexible polyimide films with that of reduced graphene oxide nanosheets for laser-gated pathogen inactivation. In vivo tests performed on mice with subcutaneous skin infection and treated with the photothermal skin patch show wound healing of the infected site, while nontreated areas result in necrotic muscular fibers and bacterial infiltrate. No loss in efficiency is observed upon multiple use of these patches during in vivo experiments because of their robustness.Show less >
Show more >Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic penetration to bacterial infection sites as well as the development of antibiotic-resistant pathogens. In the case of skin infection, the wound is covered by exudate, making it impermeable to topical antibiotics. The development of a flexible patch allowing a rapid and highly efficient treatment of subcutaneous wound infections via photothermal irradiation is presented here. The skin patch combines the near-infrared photothermal properties of a gold nanohole array formed by self-assembly of colloidal structures on flexible polyimide films with that of reduced graphene oxide nanosheets for laser-gated pathogen inactivation. In vivo tests performed on mice with subcutaneous skin infection and treated with the photothermal skin patch show wound healing of the infected site, while nontreated areas result in necrotic muscular fibers and bacterial infiltrate. No loss in efficiency is observed upon multiple use of these patches during in vivo experiments because of their robustness.Show less >
Language :
Anglais
Administrative institution(s) :
Institut Catholique Lille
Université de Lille
ISEN
Univ. Valenciennes
CNRS
INRA
ISA
Centrale Lille
Univ. Artois
Univ. Littoral Côte d’Opale
Université de Lille
ISEN
Univ. Valenciennes
CNRS
INRA
ISA
Centrale Lille
Univ. Artois
Univ. Littoral Côte d’Opale
Collections :
Research team(s) :
Computational Molecular Systems Biology
Submission date :
2020-02-12T15:11:23Z