O-GlcNAcylation, an Epigenetic Mark. Focus ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins
Author(s) :
Dehennaut, Vanessa [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Leprince, Dominique [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Lefebvre, Tony [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Institut de biologie de Lille - IBL [IBLI]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Leprince, Dominique [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Lefebvre, Tony [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Journal title :
Frontiers in endocrinology
Abbreviated title :
Front Endocrinol (Lausanne)
Volume number :
5
Pages :
155
Publication date :
2014-09-26
ISSN :
1664-2392
English keyword(s) :
polycomb
Histones
O-GlcNAcylation
cancer
Epigenetic
TET family proteins
OGT
Histones
O-GlcNAcylation
cancer
Epigenetic
TET family proteins
OGT
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
There are increasing evidences that dietary components and metabolic disorders affect gene expression through epigenetic mechanisms. These observations support the notion that epigenetic reprograming-linked nutrition is ...
Show more >There are increasing evidences that dietary components and metabolic disorders affect gene expression through epigenetic mechanisms. These observations support the notion that epigenetic reprograming-linked nutrition is connected to the etiology of metabolic diseases and cancer. During the last 5 years, accumulating data revealed that the nutrient-sensing O-GlcNAc glycosylation (O-GlcNAcylation) may be pivotal in the modulation of chromatin remodeling and in the regulation of gene expression by being part of the "histone code," and by identifying OGT (O-GlcNAc transferase) as an interacting partner of the TET family proteins of DNA hydroxylases and as a member of the polycomb group proteins. Thus, it is suggested that O-GlcNAcylation is a post-translational modification that links nutrition to epigenetic. This review summarizes recent findings about the interplay between O-GlcNAcylation and the epigenome and enlightens the contribution of the glycosylation to epigenetic reprograming.Show less >
Show more >There are increasing evidences that dietary components and metabolic disorders affect gene expression through epigenetic mechanisms. These observations support the notion that epigenetic reprograming-linked nutrition is connected to the etiology of metabolic diseases and cancer. During the last 5 years, accumulating data revealed that the nutrient-sensing O-GlcNAc glycosylation (O-GlcNAcylation) may be pivotal in the modulation of chromatin remodeling and in the regulation of gene expression by being part of the "histone code," and by identifying OGT (O-GlcNAc transferase) as an interacting partner of the TET family proteins of DNA hydroxylases and as a member of the polycomb group proteins. Thus, it is suggested that O-GlcNAcylation is a post-translational modification that links nutrition to epigenetic. This review summarizes recent findings about the interplay between O-GlcNAcylation and the epigenome and enlightens the contribution of the glycosylation to epigenetic reprograming.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
CNRS
Université de Lille
Université de Lille
Collections :
Research team(s) :
O-GlcNAcylation, signalisation cellulaire et cycle cellulaire
Submission date :
2020-02-12T15:11:52Z
2021-03-12T13:17:38Z
2021-03-12T13:17:38Z
Files
- fendo-05-00155.pdf
- Version éditeur
- Open access
- Access the document