Titre :

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Auteur(s) :

Di Menna, Luisa [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Joffe, Max E. [Auteur]
Vanderbilt University Medical Center [Nashville]
Iacovelli, Luisa [Auteur]
Department of Psychology [University of Roma "La Sapienza"]
Orlando, Rosamaria [Auteur]
Department of Psychology [University of Roma "La Sapienza"]
Lindsley, Craig W. [Auteur]
Vanderbilt University [Nashville]
Mairesse, Jérôme [Auteur]
Université Sorbonne Paris Cité [USPC]
Gressèns, Pierre [Auteur]
Université Paris Cité [UPCité]
Cannella, Milena [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Caraci, Filippo [Auteur]
Università degli studi di Catania = University of Catania [Unict]
Copani, Agata [Auteur]
Università degli studi di Catania = University of Catania [Unict]
Bruno, Valeria [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Battaglia, Giuseppe [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Conn, P. Jeffrey [Auteur]
Vanderbilt University Medical Center [Nashville]
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]

Titre de la revue :

Neuropharmacology

Numéro :

128

Pagination :

301-313

Date de publication :

2018-01

ISSN :

00283908

Mot(s)-clé(s) en anglais :

G-protein βγ subunits
Long-term depression
Metabotropic glutamate receptors
Neurodevelopment
Neuronal death
Polyphosphoinositide hydrolysis
Receptor-receptor cross-talk
Synaptic plasticity

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

mGlu5 receptors are involved in mechanisms of activity-dependent synaptic plasticity, and are targeted by drugs developed for the treatment of CNS disorders. We report that mGlu3 receptors, which are traditionally linked ...
Lire la suite >mGlu5 receptors are involved in mechanisms of activity-dependent synaptic plasticity, and are targeted by drugs developed for the treatment of CNS disorders. We report that mGlu3 receptors, which are traditionally linked to the control of neurotransmitter release, support mGlu5 receptor signaling in neurons and largely contribute to the robust mGlu5 receptor-mediated polyphosphoinositide hydrolysis in the early postnatal life. In cortical pyramidal neurons, mGlu3 receptor activation potentiated mGlu5 receptor-mediated somatic Ca2+ mobilization, and mGlu3 receptor-mediated long-term depression in the prefrontal cortex required the endogenous activation of mGlu5 receptors. The interaction between mGlu3 and mGlu5 receptors was also relevant to mechanisms of neuronal toxicity, with mGlu3 receptors shaping the influence of mGlu5 receptors on excitotoxic neuronal death. These findings shed new light into the complex role played by mGlu receptors in physiology and pathology, and suggest reconsideration of some of the current dogmas in the mGlu receptor field.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CNRS
Université de Lille

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Glycostress

Date de dépôt :

2020-02-12T15:12:21Z
2024-02-23T09:31:25Z