Title :

New insights into the biological role of the osmoregulated periplasmic glucans in pathogenic and symbiotic bacteria: OPG biological role

Author(s) :

bontemps-gallo, sébastien [Auteur]
National Institute of Allergy and Infectious Diseases [Bethesda] [NIAID-NIH]
Lacroix, Jean-Marie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]

Journal title :

Environmental Microbiology Reports

Volume number :

7

Pages :

690-697

Publication date :

2015-10

ISSN :

17582229

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

This review emphasizes the biological roles of the osmoregulated periplasmic glucans (OPGs). OPGs occur in almost all α, β and γ Proteobacteria. This polymer of glucose is required for full virulence. The roles of the OPGs ...
Show more >This review emphasizes the biological roles of the osmoregulated periplasmic glucans (OPGs). OPGs occur in almost all α, β and γ Proteobacteria. This polymer of glucose is required for full virulence. The roles of the OPGs are complex and vary depending on the species. Here, we outline the four major roles of the OPGs through four different pathogenic and one symbiotic bacterial models (Dickeya dadantii, Salmonella enterica, Pseudomonas aeruginosa, Brucella abortus and Sinorhizobium meliloti). When periplasmic, the OPGs are a part of the signal transduction pathway and indirectly regulate genes involved in virulence. The OPGs can also be secreted. When outside of the cell, they interact directly with antibiotics to protect the bacterial cell or interact with the host cell to facilitate the invasion process. When OPGs are not found, as in the ε Proteobacteria, OPG-like oligosaccharides are present. Their presence strengthens the evidence that OPGs play an important role in virulence.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

CNRS
Université de Lille

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Génétique des enveloppes bactériennes

Submission date :

2020-02-12T15:44:39Z
2021-02-26T08:08:27Z