A library of heptyl mannose-functionalized ...
Document type :
Article dans une revue scientifique
DOI :
Permalink :
Title :
A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli
Author(s) :
Yan, Xibo [Auteur]
Ingénierie des Matériaux Polymères [IMP]
Sivignon, Adeline [Auteur]
Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH]
Barnich, Nicolas [Auteur]
Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH]
Gouin, Sébastien G. [Auteur]
Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation [CEISAM]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Fleury, Etienne [Auteur]
Ingénierie des Matériaux Polymères [IMP]
Bernard, Julien [Auteur]
Ingénierie des Matériaux Polymères [IMP]
Ingénierie des Matériaux Polymères [IMP]
Sivignon, Adeline [Auteur]
Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH]
Barnich, Nicolas [Auteur]
Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH]
Gouin, Sébastien G. [Auteur]
Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation [CEISAM]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Fleury, Etienne [Auteur]
Ingénierie des Matériaux Polymères [IMP]
Bernard, Julien [Auteur]
Ingénierie des Matériaux Polymères [IMP]
Journal title :
Polymer Chemistry
Volume number :
7
Pages :
2674-2683
Publication date :
2016
ISSN :
1759-9954, 1759-9962
English keyword(s) :
affinity
recognition
glycopolymers
raft polymerization
multivalent interactions
controlled radical polymerization
lectin binding
architecture
inhibition
density
recognition
glycopolymers
raft polymerization
multivalent interactions
controlled radical polymerization
lectin binding
architecture
inhibition
density
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
A large library of mannosylated copolymers having tunable compositions, microstructures and pendant motifs neighboring mannose of distinct nature were synthesized by combining (i) sequential, batch or semi-batch RAFT ...
Show more >A large library of mannosylated copolymers having tunable compositions, microstructures and pendant motifs neighboring mannose of distinct nature were synthesized by combining (i) sequential, batch or semi-batch RAFT (co)polymerizations of glycidyl methacrylate (GMA) and N-[7-(α-D-mannopyranosyloxy)heptyl] methacrylamide (HMM) and (ii) epoxy-amine post-modifications with ethanolamine, (2-aminoethyl)trimethylammonium chloride or taurine. Examination of the anti-adhesive properties against type 1 piliated E. coli allowed for identifying copolymers among the three series of post-modified glycopolymers capable of efficiently inhibiting bacterial adhesion at 0.1 and 1 μM (on a mannose unit basis) in pre and post-incubation adhesion assays respectively.Show less >
Show more >A large library of mannosylated copolymers having tunable compositions, microstructures and pendant motifs neighboring mannose of distinct nature were synthesized by combining (i) sequential, batch or semi-batch RAFT (co)polymerizations of glycidyl methacrylate (GMA) and N-[7-(α-D-mannopyranosyloxy)heptyl] methacrylamide (HMM) and (ii) epoxy-amine post-modifications with ethanolamine, (2-aminoethyl)trimethylammonium chloride or taurine. Examination of the anti-adhesive properties against type 1 piliated E. coli allowed for identifying copolymers among the three series of post-modified glycopolymers capable of efficiently inhibiting bacterial adhesion at 0.1 and 1 μM (on a mannose unit basis) in pre and post-incubation adhesion assays respectively.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
CNRS
Université de Lille
Université de Lille
Research team(s) :
Computational Molecular Systems Biology
Submission date :
2020-02-12T15:44:45Z
2021-04-22T13:41:02Z
2021-04-22T13:41:02Z