Title :

Affinity of Glycan-Modified Nanodiamonds towards Lectins and Uropathogenic Escherichia Coli

Author(s) :

Turcheniuk, Volodymyr [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Turcheniuk, Kostiantyn [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Barras, Alexandre [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Dumych, Tetiana [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Bilyy, Rostyslav [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Zaitsev, Vladimir [Auteur]
Taras Shevchenko National University of Kyiv
Siriwardena, Aloysius [Auteur]
Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 [LG2A ]
Wang, Qi [Auteur]
Shandong University
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]

Journal title :

ChemNanoMat

Volume number :

2

Pages :

307-314

Publication date :

2016-04

ISSN :

2199-692X

English keyword(s) :

Affinity
Escherichia coli
Glycans
Nanodiamonds
Photo-coupling

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Nanodiamond particles (NDs) modified with glycan ligands are revealing themselves to have great promise as new nanomaterials for combating biofilm formation and as promising anti‐adhesive scaffolds. Currently, the strategies ...
Show more >Nanodiamond particles (NDs) modified with glycan ligands are revealing themselves to have great promise as new nanomaterials for combating biofilm formation and as promising anti‐adhesive scaffolds. Currently, the strategies at hand to formulate glycan‐modified NDs (glyco‐NDs) are limited to a few reports. We demonstrate herein that the photoinduced covalent attachment of unmodified sugars results in glyco‐NDs with high binding affinity to lectins and a uropathogenic Escherichia coli strain (E. coli UTI89). While the binding affinities of glyco‐NDs to different lectins is partially sacrificed when monosaccharides such as mannose are photochemically integrated onto NDs, in the case of disaccharides and oligosaccharides the binding affinity of glyco‐NDs to lectins is preserved. Moreover, mannan‐modified NDs show strong interactions with uropathogenic E. coli., suggesting the effectiveness of photochemically formed glyco‐NDs for disruption of E. coli‐mediated biofilms.Show less >

Language :

Anglais

Audience :

Non spécifiée

European Project :

Fabrication of particles with photo receptors: bio-analytical application such as controlled drug delivery
Pathogen and Graphene

Administrative institution(s) :

Institut Catholique Lille
Université de Lille
ISEN
Univ. Valenciennes
CNRS
Centrale Lille

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Computational Molecular Systems Biology

Submission date :

2020-02-12T15:44:46Z
2021-04-23T08:26:47Z