Title :

Particle-based photodynamic therapy based on indocyanine green modified plasmonic nanostructures for inactivation of a Crohn's disease-associated Escherichia coli strain

Author(s) :

Jijie, Roxana [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Alexandru Ioan Cuza University of Iași = Universitatea Alexandru Ioan Cuza din Iași [UAIC]
Dumych, Tetiana [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Li, Chengnan [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Turcheniuk, Kostiantyn [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Hage, Charles-Henri [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
XLIM [XLIM]
Heliot, Laurent [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
XLIM [XLIM]
Cudennec, Benoit [Auteur]
Institut Charles Viollette (ICV) - EA 7394 [ICV]
Dumitrascu, Nicoleta [Auteur]
Alexandru Ioan Cuza University of Iași = Universitatea Alexandru Ioan Cuza din Iași [UAIC]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]

Journal title :

Journal of Materials Chemistry B

Volume number :

4

Pages :

2598-2605

Publication date :

2016

ISSN :

2050-750X

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Particle-based photodynamic therapy (PPDT) holds great promise in theranostic applications. Herein, we demonstrate that PPDT based on gold nanorods coated with an indocyanine green (ICG)-loaded silica shell allows for the ...
Show more >Particle-based photodynamic therapy (PPDT) holds great promise in theranostic applications. Herein, we demonstrate that PPDT based on gold nanorods coated with an indocyanine green (ICG)-loaded silica shell allows for the inactivation of the Crohn's disease-associated adherent-invasive Escherichia coli strain LF82 (E. coli LF82) under pulsed laser light irradiation at 810 nm. Fine-tuning of the plasmonic structures together with maximizing the photosensitizer loading onto the nanostructures allowed optimizing the singlet oxygen generation capability and the PPDT efficiency. Using a nanoparticle concentration low enough to suppress photothermal heating effects, 6 log10 reduction in E. coli LF82 viability could be achieved using gold nanostructures displaying a plasmonic band at 900 nm. An additional modality of nanoparticle-based photoinactivation of E. coli is partly observed, with 3 log10 reduction of bacterial viability using Au NRs@SiO2 without ICG, due to the two-photon induced formation of reactive oxygen species. Interaction of the particles with the bacterial surface, responsible for the disruption of the bacterial integrity, together with the generation of moderate quantities of singlet oxygen could account for this behavior.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

Institut Catholique Lille
Université de Lille
ISEN
Univ. Valenciennes
CNRS
INRA
ISA
Centrale Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• BioEcoAgro - UMR-T 1158
• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
• Laboratoire de Physique des Lasers, Atomes et Molécules (PhLAM) - UMR 8523
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Computational Molecular Systems Biology

Submission date :

2020-02-12T15:44:46Z
2021-04-23T06:46:40Z