Title :

Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

Author(s) :

Turcheniuk, Kostiantyn [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Dumych, Tetiana [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Bilyy, Rostyslav [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Turcheniuk, Volodymyr [Auteur]
Taras Shevchenko National University of Kyiv
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Vovk, Volodymyr [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Chopyak, Valentyna [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Zaitsev, Vladimir [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Mariot, Pascal [Auteur]
Physiologie Cellulaire (PHYCELL) - U1003
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Prevarskaya, Natalia [Auteur]
Physiologie Cellulaire (PHYCELL) - U1003
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]

Journal title :

RSC Advances

Volume number :

6

Pages :

1600-1610

Publication date :

2016

ISSN :

2046-2069

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

Gold nanorods (Au NRs) are known for their efficient conversion of photon energy into heat, resulting in hyperthermia and suppression of tumor growth in vitro and in vivo. Au NRs are thus of great promise for photothermal ...
Show more >Gold nanorods (Au NRs) are known for their efficient conversion of photon energy into heat, resulting in hyperthermia and suppression of tumor growth in vitro and in vivo. Au NRs are thus of great promise for photothermal therapy (PTT) of different cancers. From the point of cancer therapy, low laser powers are essential (≤1 W cm−2) to ensure minimal side effects such as skin burning. Herein, we investigate the potential of polyethylene glycol functionalized reduced graphene oxide (rGO-PEG) enrobed Au NRs for the photothermal destruction of human glioblastoma astrocytoma (U87MG) cells in mice. We show that Au NRs@rGO-PEG are ideal multifunctional theranostic nanostructures that can exert efficient photothermal destruction of tumors in mice upon low doses of NIR light excitation and can act as fluorescent cellular markers due to the presence of a NIR dye integrated onto the rGO shell. Due to the specific interaction between Tat protein modified Au NRs@rGO-PEG nanostructures with the human glioblastoma astrocytoma (U87MG) cells, selective targeting of the tumor is achieved. In vivo experiments in mice show that upon irradiation of the tumor implanted in mice at 800 nm under low doses (0.7 W cm−2), U87MG tumor growth gets suppressed. The study demonstrates that the novel nanomaterials allow for an efficient destruction of solid tumors and might thus serve as an excellent multi-functional theranostic agent in photothermal therapeutic applications.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

ISEN
Univ. Valenciennes
CNRS
Inserm
Institut Catholique Lille
Centrale Lille
Université de Lille

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
• Physiologie Cellulaire (PHYCELL) - U1003
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Computational Molecular Systems Biology

Submission date :

2020-02-12T15:44:46Z
2021-04-23T07:19:39Z