Titre :

Sequestration of host metabolism by an intracellular pathogen

Auteur(s) :

Gehre, Lena [Auteur]
Biologie cellulaire de l'Infection microbienne - Cellular Biology of Microbial Infection
Gorgette, Olivier [Auteur]
Microscopie ultrastructurale (plate-forme)
Perrinet, Stéphanie [Auteur]
Biologie cellulaire de l'Infection microbienne - Cellular Biology of Microbial Infection
Prevost, Marie-Christine [Auteur]
Microscopie Ultrastructurale (Plate-forme)
Ducatez, Mathieu [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Giebel, Amanda M [Auteur]
Department of Biology [Bloomington]
Nelson, David E [Auteur]
Indiana University School of Medicine
Ball, Steven [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Subtil, Agathe [Auteur]
Biologie cellulaire de l'infection microbienne

Titre de la revue :

eLife

Numéro :

5

Date de publication :

2016-03-16

ISSN :

2050-084X

Mot(s)-clé(s) en anglais :

cell biology
chlamydia trachomatis
glycogen metabolism
host-pathogens interactions
human
infectious desease
intracellular parasites
microbiology

Discipline(s) HAL :

Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

For intracellular pathogens, residence in a vacuole provides a shelter against cytosolichost defense to the cost of limited access to nutrients. The human pathogenChlamydiatrachomatisgrows in a glycogen-rich vacuole. How ...
Lire la suite >For intracellular pathogens, residence in a vacuole provides a shelter against cytosolichost defense to the cost of limited access to nutrients. The human pathogenChlamydiatrachomatisgrows in a glycogen-rich vacuole. How this large polymer accumulates there isunknown. We reveal that host glycogen stores shift to the vacuole through two pathways: bulkuptake from the cytoplasmic pool, andde novosynthesis. We provide evidence that bacterialglycogen metabolism enzymes are secreted into the vacuole lumen through type 3 secretion. Ourdata bring strong support to the following scenario: bacteria co-opt the host transporter SLC35D2to import UDP-glucose into the vacuole, where it serves as substrate forde novoglycogensynthesis, through a remarkable adaptation of the bacterial glycogen synthase. Based on thesefindings we propose that parasitophorous vacuoles not only offer protection but also provide amicroorganism-controlled metabolically active compartment essential for redirecting host resourcesto the pathogens.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

CNRS
Université de Lille

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Génétique microbienne

Date de dépôt :

2020-02-12T15:45:11Z
2021-03-11T10:07:01Z