Title :

Norine: update of the nonribosomal peptide resource

Author(s) :

Flissi, Areski [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Ricart, Emma [Auteur]
Université de Genève = University of Geneva [UNIGE]
Swiss Institute of Bioinformatics [Genève] [SIB]
Campart, Clémentine [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Chevalier, Mickael [Auteur]
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Dufresne, Yoann [Auteur]
Département de Biologie Computationnelle - Department of Computational Biology
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Michalik, Juraj [Auteur]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Jacques, Philippe [Auteur]
Flahaut, Christophe [Auteur]
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Lisacek, Frederique [Auteur]
Université de Genève = University of Geneva [UNIGE]
Swiss Institute of Bioinformatics [Genève] [SIB]
Leclere, Valerie [Auteur]
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Pupin, Maude [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]

Journal title :

Nucleic acids research

Publisher :

Oxford University Press

Publication date :

2019

ISSN :

0305-1048

HAL domain(s) :

Sciences du Vivant [q-bio]
Informatique [cs]

English abstract : [en]

Norine, the unique resource dedicated to nonribo-somal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet ...
Show more >Norine, the unique resource dedicated to nonribo-somal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet in Norine. To maintain a high data quality, successive filters are applied to automatically validate the NRP annotations and only validated data is inserted in the database. External databases were also used to complete annotations of NRPs already in Norine. Besides, annotation consistency inside Norine and between Norine and external sources have reported annotation errors. Some can be corrected automatically, while others need manual curation. This new approach led to the insertion of 539 new NRPs and the addition or correction of annotations of nearly all Norine entries. Two new tools to analyse the chemical structures of NRPs (rBAN) and to infer a molecular formula from the mass-to-charge ratio of an NRP (Kendrick Formula Predictor) were also integrated. Norine is freely accessible from the following URL: https://bioinfo.cristal.univ-lille.fr/ norine/Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Institut français de bioinformatique

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL