A zwitterionic interpenetrating network ...
Type de document :
Compte-rendu et recension critique d'ouvrage
Titre :
A zwitterionic interpenetrating network for improving the blood compatibility of polypropylene membranes applied to leukodepletion
Auteur(s) :
Lien, Cheng-Chi [Auteur]
Chung Yuan Christian University
Chen, Po-Ju [Auteur]
Chung Yuan Christian University
Venault, Antoine [Auteur]
Chung Yuan Christian University
Tang, Shuo-Hsi [Auteur]
Chung Yuan Christian University
Fu, Ying [Auteur]
Chung Yuan Christian University
Dizon, Gian [Auteur]
Chung Yuan Christian University
Aimar, Pierre [Auteur]
Laboratoire de Génie Chimique [LGC]
Chang, Yung [Auteur]
Chung Yuan Christian University
Chung Yuan Christian University
Chen, Po-Ju [Auteur]
Chung Yuan Christian University
Venault, Antoine [Auteur]
Chung Yuan Christian University
Tang, Shuo-Hsi [Auteur]
Chung Yuan Christian University
Fu, Ying [Auteur]
Chung Yuan Christian University
Dizon, Gian [Auteur]
Chung Yuan Christian University
Aimar, Pierre [Auteur]
Laboratoire de Génie Chimique [LGC]
Chang, Yung [Auteur]
Chung Yuan Christian University
Titre de la revue :
Journal of Membrane Science
Pagination :
148-160
Éditeur :
Elsevier
Date de publication :
2019
ISSN :
0376-7388
Mot(s)-clé(s) en anglais :
PP membranes
Interpenetrating network
Antifouling
Leukodepletion
Poly(GMA-co-SBMA)
Interpenetrating network
Antifouling
Leukodepletion
Poly(GMA-co-SBMA)
Discipline(s) HAL :
Chimie/Polymères
Chimie/Génie chimique
Sciences de l'ingénieur [physics]/Génie des procédés
Chimie/Génie chimique
Sciences de l'ingénieur [physics]/Génie des procédés
Résumé en anglais : [en]
Although widely used in blood-contacting devices, polypropylene (PP) membranes are prone to biofouling by plasma proteins and blood cells. The present study explores the effect of a surface zwitterionization process on the ...
Lire la suite >Although widely used in blood-contacting devices, polypropylene (PP) membranes are prone to biofouling by plasma proteins and blood cells. The present study explores the effect of a surface zwitterionization process on the improvement of the biofouling resistance of PP membranes for leukocyte reduction filters. The modification strategy consists in forming an interpenetrating network of poly(glycidyl methacrylate-co-sulfobetaine methacrylate) (poly(GMA-co-SBMA) around the fibers of coated PP membranes, using a cross-linking agent: ethylenediamine (EDA). It is shown that with EDA, a range of poly(GMA-co-SBMA) concentration (1–5 mg/mL) leads to a 0°-water contact angle and high hydration of the networks without affecting the intrinsic porous structure of the material. Besides, the related membranes show excellent resistance to biofouling by Escherichia coli, fibrinogen, leukocytes, erythrocytes, thrombocytes and cells from whole blood with reductions in adsorption of 97%, 86%, 90%, 95%, 97% and 91%, respectively, compared to unmodified PP. Used in whole blood filtration, it is demonstrated that in the best conditions (5 mg/mL copolymer, with EDA), leukocytes can be efficiently removed (>99.99%) without altering the erythrocytes concentration in the permeate, and that leukodepletion is more efficient than that measured with a commercial hydrophilic PP blood filter (about 50% retention). Physical retention of leukocytes is only efficient if the membrane material is anti-biofouling, and so, does not interact with other blood components able to trigger leukocyte attachment/deformation.Lire moins >
Lire la suite >Although widely used in blood-contacting devices, polypropylene (PP) membranes are prone to biofouling by plasma proteins and blood cells. The present study explores the effect of a surface zwitterionization process on the improvement of the biofouling resistance of PP membranes for leukocyte reduction filters. The modification strategy consists in forming an interpenetrating network of poly(glycidyl methacrylate-co-sulfobetaine methacrylate) (poly(GMA-co-SBMA) around the fibers of coated PP membranes, using a cross-linking agent: ethylenediamine (EDA). It is shown that with EDA, a range of poly(GMA-co-SBMA) concentration (1–5 mg/mL) leads to a 0°-water contact angle and high hydration of the networks without affecting the intrinsic porous structure of the material. Besides, the related membranes show excellent resistance to biofouling by Escherichia coli, fibrinogen, leukocytes, erythrocytes, thrombocytes and cells from whole blood with reductions in adsorption of 97%, 86%, 90%, 95%, 97% and 91%, respectively, compared to unmodified PP. Used in whole blood filtration, it is demonstrated that in the best conditions (5 mg/mL copolymer, with EDA), leukocytes can be efficiently removed (>99.99%) without altering the erythrocytes concentration in the permeate, and that leukodepletion is more efficient than that measured with a commercial hydrophilic PP blood filter (about 50% retention). Physical retention of leukocytes is only efficient if the membrane material is anti-biofouling, and so, does not interact with other blood components able to trigger leukocyte attachment/deformation.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Collections :
Source :
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