Title :

Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.

Author(s) :

Beltran, Sophie [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Laboratoire Écologie, Évolution, Symbiose [UMR 6556 – Poitiers] [LEES]
Gourbal, Benjamin [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Boissier, Jérôme [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Duval, David [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Kieffer-Jaquinod, S. [Auteur]
Institut de Biosciences et de Biotechnologies de Grenoble (ex-IRTSV) [BIG]
Pierce, R. J. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Grunau, Christoph [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Théron, A. [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]
Mitta, G. [Auteur]
Biologie et écologie tropicale et méditerranéenne [2007-2010] [BETM]

Journal title :

Journal of Evolutionary Biology

Pages :

554-72

Publisher :

Wiley

Publication date :

2011-03

ISSN :

1010-061X

HAL domain(s) :

Sciences de l'environnement/Biodiversité et Ecologie

English abstract : [en]

Schistosomes are gonochoric blood parasites with a complex life cycle responsible for a disease of considerable medical and veterinary importance in tropical and subtropical regions. Understanding the evolution of schistosome ...
Show more >Schistosomes are gonochoric blood parasites with a complex life cycle responsible for a disease of considerable medical and veterinary importance in tropical and subtropical regions. Understanding the evolution of schistosome genetic diversity is clearly of fundamental importance to interpreting schistosomiasis epidemiology and disease transmission patterns of this parasite. In this article, we investigated the putative role of the host immune system in the selection of male genetic diversity. We demonstrated the link between genetic dissimilarity and the protective effect among male worms. We then compared the proteomes of three male clones with different genotypes and differing by their capacity to protect against reinfection. The identified differences correspond mainly to antigens known or supposed to be involved in the induction of protective immunity. These results underline the role played by host immune system in the selection of schistosome genetic diversity that is linked to antigenic diversity. We discuss the evolutionary consequences in the context of schistosome infection.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL