Lumen areas and homothety factor influence ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Lumen areas and homothety factor influence airway resistance in COPD.
Auteur(s) :
Bokov, Plamen [Auteur]
Mauroy, Benjamin [Auteur]
Revel, Marie-Pierre [Auteur]
Brun, Pierre-Amaury [Auteur]
Peiffer, Claudine [Auteur]
Daniel, Christel [Auteur]
Nay, Maria-Magdalena [Auteur]
Mahut, Bruno [Auteur]
Delclaux, Christophe [Auteur]
Mauroy, Benjamin [Auteur]
Revel, Marie-Pierre [Auteur]
Brun, Pierre-Amaury [Auteur]
Peiffer, Claudine [Auteur]
Daniel, Christel [Auteur]
Nay, Maria-Magdalena [Auteur]
Mahut, Bruno [Auteur]
Delclaux, Christophe [Auteur]
Titre de la revue :
Respiratory Physiology and Neurobiology
Nom court de la revue :
Respir Physiol Neurobiol
Numéro :
173
Pagination :
1-10
Éditeur :
Elsevier
Date de publication :
2010-08-31
ISSN :
1569-9048
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
Résumé en anglais : [en]
The remodelling process of COPD may affect both airway calibre and the homothety factor, which is a constant parameter describing the reduction of airway lumen (h(d): diameter of child\/parent bronchus) that might be ...
Lire la suite >The remodelling process of COPD may affect both airway calibre and the homothety factor, which is a constant parameter describing the reduction of airway lumen (h(d): diameter of child\/parent bronchus) that might be critical because its reduction would induce a frank increase in airway resistance. Airway dimensions were obtained from CT scan images of smokers with (n=22) and without COPD (n=9), and airway resistance from plethysmography. Inspiratory airway resistance correlated to lumen area of the sixth bronchial generation of right lung, while peak expiratory flow correlated to the area of the third right generation (p=0.0009, R=0.57). A significant relationship was observed between h(d) and resistance (p=0.036; R(2)=0.14). A modelling approach of central airways (5 generations) further described the latter relationship. In conclusion, a constant homothety factor can be described by CT scan analysis, which partially explains inspiratory resistance, as predicted by theoretical arguments. Airway resistance is related to lumen areas of less proximal airways than commonly admitted.Lire moins >
Lire la suite >The remodelling process of COPD may affect both airway calibre and the homothety factor, which is a constant parameter describing the reduction of airway lumen (h(d): diameter of child\/parent bronchus) that might be critical because its reduction would induce a frank increase in airway resistance. Airway dimensions were obtained from CT scan images of smokers with (n=22) and without COPD (n=9), and airway resistance from plethysmography. Inspiratory airway resistance correlated to lumen area of the sixth bronchial generation of right lung, while peak expiratory flow correlated to the area of the third right generation (p=0.0009, R=0.57). A significant relationship was observed between h(d) and resistance (p=0.036; R(2)=0.14). A modelling approach of central airways (5 generations) further described the latter relationship. In conclusion, a constant homothety factor can be described by CT scan analysis, which partially explains inspiratory resistance, as predicted by theoretical arguments. Airway resistance is related to lumen areas of less proximal airways than commonly admitted.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Date de dépôt :
2020-06-08T14:10:40Z
2021-05-14T13:22:21Z
2021-05-14T13:22:21Z