Title :

Interictal epileptic discharge correlates with global and frontal cognitive dysfunction in temporal lobe epilepsy

Author(s) :

Dinkelacker, Vera [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
Xin, Xu [Auteur]
Tsinghua University [Beijing] [THU]
Baulac, Michel [Auteur]
Samson, Severine [Auteur]
Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC]
Dupont, Sophie [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]

Journal title :

Epilepsy & Behavior

Abbreviated title :

E&B

Volume number :

62

Pages :

p. 197-203

Publication date :

2016-09

ISSN :

1525-5069

English keyword(s) :

Epilepsy
Executive function
Hippocampal sclerosis
Interictal activity
Neuropsychology.

HAL domain(s) :

Sciences cognitives

English abstract : [en]

OBJECTIVE Temporal lobe epilepsy (TLE) with hippocampal sclerosis has widespread effects on structural and functional connectivity and often entails cognitive dysfunction. EEG is mandatory to disentangle interactions in ...
Show more >OBJECTIVE Temporal lobe epilepsy (TLE) with hippocampal sclerosis has widespread effects on structural and functional connectivity and often entails cognitive dysfunction. EEG is mandatory to disentangle interactions in epileptic and physiological networks which underlie these cognitive comorbidities. Here, we examined how interictal epileptic discharges (IEDs) affect cognitive performance. METHODS Thirty-four patients (right TLE=17, left TLE=17) were examined with 24-hour video-EEG and a battery of neuropsychological tests to measure intelligence quotient and separate frontal and temporal lobe functions. Hippocampal segmentation of high-resolution T1-weighted imaging was performed with FreeSurfer. Partial correlations were used to compare the number and distribution of clinical interictal spikes and sharp waves with data from imagery and psychological tests. RESULTS The number of IEDs was negatively correlated with executive functions, including verbal fluency and intelligence quotient (IQ). Interictal epileptic discharge affected cognitive function in patients with left and right TLE differentially, with verbal fluency strongly related to temporofrontal spiking. In contrast, IEDs had no clear effects on memory functions after corrections with partial correlations for age, age at disease onset, disease duration, and hippocampal volume. CONCLUSION In patients with TLE of long duration, IED occurrence was strongly related to cognitive deficits, most pronounced for frontal lobe function. These data suggest that IEDs reflect dysfunctional brain circuitry and may serve as an independent biomarker for cognitive comorbidity.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille

Collections :

• Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - ULR 4072

Research team(s) :

Neuropsychologie & Audition

Submission date :

2020-09-14T10:32:40Z
2023-04-27T07:57:01Z