Titre :

Interictal epileptic discharge correlates with global and frontal cognitive dysfunction in temporal lobe epilepsy

Auteur(s) :

Dinkelacker, Vera [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]
Xin, Xu [Auteur]
Tsinghua University [Beijing] [THU]
Baulac, Michel [Auteur]
Samson, Severine [Auteur]
Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC]
Dupont, Sophie [Auteur]
Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute [ICM]

Titre de la revue :

Epilepsy & Behavior

Nom court de la revue :

E&B

Numéro :

62

Pagination :

p. 197-203

Date de publication :

2016-09

ISSN :

1525-5069

Mot(s)-clé(s) en anglais :

Epilepsy
Executive function
Hippocampal sclerosis
Interictal activity
Neuropsychology.

Discipline(s) HAL :

Sciences cognitives

Résumé en anglais : [en]

OBJECTIVE Temporal lobe epilepsy (TLE) with hippocampal sclerosis has widespread effects on structural and functional connectivity and often entails cognitive dysfunction. EEG is mandatory to disentangle interactions in ...
Lire la suite >OBJECTIVE Temporal lobe epilepsy (TLE) with hippocampal sclerosis has widespread effects on structural and functional connectivity and often entails cognitive dysfunction. EEG is mandatory to disentangle interactions in epileptic and physiological networks which underlie these cognitive comorbidities. Here, we examined how interictal epileptic discharges (IEDs) affect cognitive performance. METHODS Thirty-four patients (right TLE=17, left TLE=17) were examined with 24-hour video-EEG and a battery of neuropsychological tests to measure intelligence quotient and separate frontal and temporal lobe functions. Hippocampal segmentation of high-resolution T1-weighted imaging was performed with FreeSurfer. Partial correlations were used to compare the number and distribution of clinical interictal spikes and sharp waves with data from imagery and psychological tests. RESULTS The number of IEDs was negatively correlated with executive functions, including verbal fluency and intelligence quotient (IQ). Interictal epileptic discharge affected cognitive function in patients with left and right TLE differentially, with verbal fluency strongly related to temporofrontal spiking. In contrast, IEDs had no clear effects on memory functions after corrections with partial correlations for age, age at disease onset, disease duration, and hippocampal volume. CONCLUSION In patients with TLE of long duration, IED occurrence was strongly related to cognitive deficits, most pronounced for frontal lobe function. These data suggest that IEDs reflect dysfunctional brain circuitry and may serve as an independent biomarker for cognitive comorbidity.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille

Collections :

• Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - ULR 4072

Équipe(s) de recherche :

Neuropsychologie & Audition

Date de dépôt :

2020-09-14T10:32:40Z
2023-04-27T07:57:01Z