Titre :

Resting-state functional connectivity of the nucleus accumbens in auditory and visual hallucinations in schizophrenia

Auteur(s) :

Rolland, Benjamin [Auteur]
Amad, Ali [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
Poulet, Emmanuel [Auteur]
Centre Hospitalier le Vinatier [Bron]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Vignaud, Alexandre [Auteur]
Service NEUROSPIN [NEUROSPIN]
Bation, Remy [Auteur]
Delmaire, Christine [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Thomas, Pierre [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
Cottencin, Olivier [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
Jardri, Renaud [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]

Titre de la revue :

Schizophrenia Bulletin

Nom court de la revue :

Schizophr. Bull.

Numéro :

41

Pagination :

291-299

Date de publication :

2014-07-21

ISSN :

0586-7614

Mot(s)-clé(s) en anglais :

MRI
salience
schizophrenia
visual
striatum
nucleus accumbens
ventral tegmental area
hallucinations
Ventral Tegmental Area/physiopathology*
Adult
Brain Mapping
Case-Control Studies
Cerebral Cortex/physiopathology
Female
Functional Neuroimaging
Gyrus Cinguli/physiopathology
Hallucinations/etiology
Hallucinations/physiopathology*
Humans
Limbic Lobe/physiopathology*
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways/physiopathology
Nucleus Accumbens/physiopathology*
Parahippocampal Gyrus/physiopathology
Putamen/physiopathology*
Schizophrenia/complications
Schizophrenia/physiopathology*
Temporal Lobe/physiopathology*
Young Adult

Discipline(s) HAL :

Sciences du Vivant [q-bio]
Sciences cognitives

Résumé en anglais : [en]

Both auditory hallucinations (AH) and visual hallucinations may occur in schizophrenia. One of the main hypotheses underlying their occurrence involves the increased activity of the mesolimbic pathway, which links the ...
Lire la suite >Both auditory hallucinations (AH) and visual hallucinations may occur in schizophrenia. One of the main hypotheses underlying their occurrence involves the increased activity of the mesolimbic pathway, which links the ventral tegmental area (VTA) and the nucleus accumbens (NAcc). However, the precise contribution of the mesolimbic pathway in hallucinations across various sensory modalities has not yet been explored. We compared the resting-state functional connectivity (rs-FC) of the NAcc among 16 schizophrenia patients with pure AH, 15 with both visuoauditory hallucinations (VAH), and 14 without hallucinations (NoH). A between-group comparison was performed using random-effects ANCOVA (rs-FC of the bilateral NAcc as the dependent variable, groups as the between-subjects factor, age and Positive and Negative Syndrome Scale scores as covariates; q(false discovery rate [FDR]) < .05). Compared to the NoH group, the AH group exhibited significantly enhanced NAcc rs-FC with the left temporal superior gyrus, the cingulate gyri, and the VTA, whereas the VAH group, compared to the AH group, exhibited significantly enhanced NAcc rs-FC with the bilateral insula, putamen, parahippocampal gyri, and VTA. The strength in rs-FC between the NAcc and the VTA appeared to be positively associated with the presence of hallucinations, but the NAcc FC patterns changed with the complexity of these experiences (ie, 0, 1, or 2 sensory modalities), rather than with severity. This might support the aberrant salience hypothesis of schizophrenia. Moreover, these findings suggest that future clinical and neurobiological studies of hallucinations should evaluate not only the global severity of symptoms but also their sensorial features.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Équipe(s) de recherche :

Équipe Psychiatrie & Croyance (PsyCHIC)

Date de dépôt :

2019-11-27T13:35:22Z
2020-04-15T09:40:08Z
2020-04-17T09:07:47Z