Dual role of the Anopheles coluzzii Venus ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Dual role of the Anopheles coluzzii Venus Kinase Receptor in both larval growth and immunity
Author(s) :
Gouignard, Nadège [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cherrier, Floriane [Auteur]
Génétique et Génomique des Insectes Vecteurs
Brito-Fravallo, Emma [Auteur]
Génétique et Génomique des Insectes Vecteurs
Pain, Adrien [Auteur]
Génétique et Génomique des Insectes Vecteurs
Zmarlak, Natalia Marta [Auteur]
Génétique et Génomique des Insectes Vecteurs
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Genève, Corinne [Auteur]
Génétique et Génomique des Insectes Vecteurs
Vernick, Kenneth D. [Auteur]
Génétique et Génomique des Insectes Vecteurs
Dissous, Colette [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Mitri, Christian [Auteur]
Génétique et Génomique des Insectes Vecteurs
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cherrier, Floriane [Auteur]
Génétique et Génomique des Insectes Vecteurs
Brito-Fravallo, Emma [Auteur]
Génétique et Génomique des Insectes Vecteurs
Pain, Adrien [Auteur]
Génétique et Génomique des Insectes Vecteurs
Zmarlak, Natalia Marta [Auteur]
Génétique et Génomique des Insectes Vecteurs
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Genève, Corinne [Auteur]
Génétique et Génomique des Insectes Vecteurs
Vernick, Kenneth D. [Auteur]
Génétique et Génomique des Insectes Vecteurs
Dissous, Colette [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Mitri, Christian [Auteur]
Génétique et Génomique des Insectes Vecteurs
Journal title :
Scientific Reports
Abbreviated title :
Sci Rep
Volume number :
9
Publisher :
Springer Science and Business Media LLC
Publication date :
2019-03-05
ISSN :
2045-2322
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Vector-borne diseases and especially malaria are responsible for more than half million deaths annually. The increase of insecticide resistance in wild populations of Anopheles malaria vectors emphasises the need for novel ...
Show more >Vector-borne diseases and especially malaria are responsible for more than half million deaths annually. The increase of insecticide resistance in wild populations of Anopheles malaria vectors emphasises the need for novel vector control strategies as well as for identifying novel vector targets. Venus kinase receptors (VKRs) constitute a Receptor Tyrosine Kinase (RTK) family only found in invertebrates. In this study we functionally characterized Anopheles VKR in the Gambiae complex member, Anopheles coluzzii. Results showed that Anopheles VKR can be activated by L-amino acids, with L-arginine as the most potent agonist. VKR was not required for the fecundity of A. coluzzii, in contrast to reports from other insects, but VKR function is required in both Anopheles males and females for development of larval progeny. Anopheles VKR function is also required for protection against infection by Plasmodium parasites, thus identifying a novel linkage between reproduction and immunity in Anopheles. The insect specificity of VKRs as well as the essential function for reproduction and immunity suggest that Anopheles VKR could be a potentially druggable target for novel vector control strategies.Show less >
Show more >Vector-borne diseases and especially malaria are responsible for more than half million deaths annually. The increase of insecticide resistance in wild populations of Anopheles malaria vectors emphasises the need for novel vector control strategies as well as for identifying novel vector targets. Venus kinase receptors (VKRs) constitute a Receptor Tyrosine Kinase (RTK) family only found in invertebrates. In this study we functionally characterized Anopheles VKR in the Gambiae complex member, Anopheles coluzzii. Results showed that Anopheles VKR can be activated by L-amino acids, with L-arginine as the most potent agonist. VKR was not required for the fecundity of A. coluzzii, in contrast to reports from other insects, but VKR function is required in both Anopheles males and females for development of larval progeny. Anopheles VKR function is also required for protection against infection by Plasmodium parasites, thus identifying a novel linkage between reproduction and immunity in Anopheles. The insect specificity of VKRs as well as the essential function for reproduction and immunity suggest that Anopheles VKR could be a potentially druggable target for novel vector control strategies.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Collections :
Research team(s) :
Régulation des signaux de division
Submission date :
2020-12-18T13:20:09Z
2021-06-08T13:13:46Z
2021-06-08T13:13:46Z
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