Title :

Cancer brings forward oviposition in the fly Drosophila melanogaster

Author(s) :

Arnal, Audrey [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Jacqueline, Camille [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Ujvari, Beata [Auteur]
Deakin University [Waurn Ponds]
Leger, Lucas [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Moreno, Céline [Auteur]
Laboratoire Evolution, Génomes et Spéciation [Gif-sur-Yvette] [LEGS]
Faugere, Dominique [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Tasiemski, Aurélie [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Wichlacz, Celine [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Missé, Dorothée [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Renaud, François [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Montagne, Jacques [Auteur]
Croissance et métabolisme chez la Drosophile [METABO]
Institut de Biologie Intégrative de la Cellule [I2BC]
Casali, Andreu [Auteur]
Roche, Benjamin [Auteur]
Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] [UMMISCO]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Mery, Frédéric [Auteur]
Laboratoire Evolution, Génomes et Spéciation [Gif-sur-Yvette] [LEGS]
Thomas, Frédéric [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]

Journal title :

Ecology and Evolution

Pages :

272 - 276

Publisher :

Wiley Open Access

Publication date :

2017

English keyword(s) :

Reproduction
Life-history strategy
Cancer
Fecundity

HAL domain(s) :

Sciences du Vivant [q-bio]/Biologie de la reproduction/Reproduction sexuée
Sciences du Vivant [q-bio]/Biologie animale/Zoologie des invertébrés

English abstract : [en]

Hosts often accelerate their reproductive effort in response to a parasitic infection, especially when their chances of future reproduction decrease with time from the onset of the infection. Because malignancies usually ...
Show more >Hosts often accelerate their reproductive effort in response to a parasitic infection, especially when their chances of future reproduction decrease with time from the onset of the infection. Because malignancies usually reduce survival, and hence potentially the fitness, it is expected that hosts with early cancer could have evolved to adjust their life-history traits to maximize their immediate reproductive effort. Despite the potential importance of these plastic responses, little attention has been devoted to explore how cancers influence animal reproduction. Here, we use an experimental setup, a colony of genetically modified flies Drosophila melanogaster which develop colorectal cancer in the anterior gut, to show the role of cancer in altering life-history traits. Specifically, we tested whether females adapt their reproductive strategy in response to harboring cancer. We found that flies with cancer reached the peak period of oviposition significantly earlier (i.e., 2 days) than healthy ones, while no difference in the length and extent of the fecundity peak was observed between the two groups of flies. Such compensatory responses to overcome the fitness-limiting effect of cancer could explain the persistence of inherited cancer-causing mutant alleles in the wild. K E Y W O R D S cancer, fecundity, life-history strategy, reproductionShow less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Evolution de la résistance naturelle au cancer : le paradoxe de Peto revisité

Collections :

• Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198

Source :

Harvested from HAL