Title :

Decrease of mutual information in brain electrical activity of patients with relapsing-remitting multiple sclerosis.

Author(s) :

Lenne, Bruno [Auteur]
Hôpital Saint Philibert [Lomme]
Blanc, Jean-Luc [Auteur]
Nandrino, Jean-Louis [Auteur]
Unité de Recherche en Sciences Cognitives et Affectives [URECA]
Gallois, Philippe [Auteur]
Hôpital Saint Philibert [Lomme]
Hautecæur, Patrick [Auteur]
Hôpital Saint Philibert [Lomme]
Pezard, Laurent [Auteur]

Journal title :

Behavioural Neurology

Abbreviated title :

Behav Neurol

Volume number :

27

Pages :

p. 201-12

Publication date :

2013

ISSN :

1875-8584

English keyword(s) :

Adult
Atrophy
Brain
Cognition
Electroencephalography
Female
Functional Laterality
Humans
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting
Nerve Net
Neuropsychological Tests
Severity of Illness Index

HAL domain(s) :

Sciences de l'Homme et Société/Psychologie

English abstract : [en]

The disturbance of cortical communication has been hypothesized as an important factor in the appearance of cognitive impairment in (MS). Cortical communication is quantified here in control subjects and patients with ...
Show more >The disturbance of cortical communication has been hypothesized as an important factor in the appearance of cognitive impairment in (MS). Cortical communication is quantified here in control subjects and patients with relapsing-remitting multiple sclerosis (RRMS) on the basis of mean coherence in the δ, θ, α, β and γ bands and using mutual information computed between pairs of bipolar EEG signals recorded during resting condition. Each patient received also a cognitive assessment using a battery of neuropsychological tests specific to cognitive deficits in MS. No difference was observed for the coherence indices whereas inter-hemispheric and right hemisphere mutual information is significantly lower in patients with MS than in control subjects. Moreover, inter-hemispheric mutual information decrease significantly with illness duration and right mutual information differentiate cognitively deficient and non-deficient patients. Mutual information allows to quantify the cortical communication in patients with RRMS and is related to clinical characteristics. Cortical communication quantified in a resting state might be a potential marker for the neurological damage induced by RRMS.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2020-12-29T09:23:11Z
2021-01-13T17:51:39Z