Title :

Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

Author(s) :

Cauwel, Madeleine [Auteur]
Sivignon, Adeline [Auteur]
Bridot, Clarisse [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Nongbe, Medy C. [Auteur]
Deniaud, David [Auteur]
Roubinet, Benoit [Auteur]
Landemarre, Ludovic [Auteur]
Felpin, François-Xavier [Auteur]
Bouckaert, Julie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Barnich, Nicolas [Auteur]
Gouin, Sébastien G. [Auteur]

Journal title :

Chemical Communications

Volume number :

55

Publisher :

Royal Society of Chemistry (RSC)

Publication date :

2019

HAL domain(s) :

Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique

English abstract : [en]

We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted ...
Show more >We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Computational Molecular Systems Biology

Submission date :

2021-01-04T08:46:08Z
2021-01-06T13:55:35Z