Chromatin remodelers as active Brownian dimers
Document type :
Article dans une revue scientifique
DOI :
Permalink :
Title :
Chromatin remodelers as active Brownian dimers
Author(s) :
Blossey, Ralf [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Schiessel, H [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Schiessel, H [Auteur]
Journal title :
Journal of Physics. A, Mathematical and Theoretical
Abbreviated title :
J. Phys. A: Math. Theor.
Volume number :
52
Pages :
085601
Publisher :
IOP Publishing
Publication date :
2019-01-29
English keyword(s) :
nucleosome
chromatin remodeler
helicase
active Brownian dimer
chromatin remodeler
helicase
active Brownian dimer
HAL domain(s) :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Chromatin remodelers are molecular motors which actively displace nucleosomes on chromatin. Recent results on the structural properties of these motors indicate that the displacement of nucleosomal DNA corresponds to an ...
Show more >Chromatin remodelers are molecular motors which actively displace nucleosomes on chromatin. Recent results on the structural properties of these motors indicate that the displacement of nucleosomal DNA corresponds to an inchworm motion induced by the generation and propagation of twist defects. Here we show that this basic action mechanism can be described by a coarse-grained active Brownian dimer (ABD) model, thereby quantitatively rationalizing the notion of inchworm motion. The model allows for extensions to more microscopic as well towards more macroscopic descriptions of chromatin hydrodynamics.Show less >
Show more >Chromatin remodelers are molecular motors which actively displace nucleosomes on chromatin. Recent results on the structural properties of these motors indicate that the displacement of nucleosomal DNA corresponds to an inchworm motion induced by the generation and propagation of twist defects. Here we show that this basic action mechanism can be described by a coarse-grained active Brownian dimer (ABD) model, thereby quantitatively rationalizing the notion of inchworm motion. The model allows for extensions to more microscopic as well towards more macroscopic descriptions of chromatin hydrodynamics.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Computational Molecular Systems Biology
Submission date :
2021-01-04T09:09:11Z
2021-01-06T15:45:48Z
2021-01-06T15:45:48Z
Files
- P19.97 blossey2019_2.pdf
- Version éditeur
- Confidential access
- Access the document