Devices based on Light Emitting Fabrics dedicated to PDTpreclinical studies

Thecua, E; Ziane, L; Baert, G; Deleporte, P.; Leroux, B.; Kumar, A.; Baydoun, M; Morales, O; Delhem, N; Mordon, Serge

Document type :

Autre communication scientifique (congrès sans actes - poster - séminaire...): Communication dans un congrès avec actes

Title :

Devices based on Light Emitting Fabrics dedicated to PDTpreclinical studies

Author(s) :

Thecua, E [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Ziane, L [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Université de Lille
Baert, G [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Deleporte, P. [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Leroux, B. [Auteur]
Kumar, A. [Auteur]
Baydoun, M [Auteur]
Morales, O [Auteur]
Delhem, N [Auteur]
Mordon, Serge [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Faculté de Médecine Henri Warembourg - Université de Lille

Conference title :

"The Feminine" 51st IPA Congress

City :

Londres

Country :

Royaume-Uni

Start date of the conference :

2019-07-24

English keyword(s) :

Light emitting fabrics
textile
optical
fibers
bending
PDT
preclinical studies
illumination
MDB TEXINOV

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Ingénierie biomédicale

English abstract : [en]

Whether preclinical studies either involve a cell or animalmodel, the distribution of light plays a determinant role in the reproducibility of results of photodynamic therapy (PDT) studies. Unfortunately, only few illumination ...
Show more >Whether preclinical studies either involve a cell or animalmodel, the distribution of light plays a determinant role in the reproducibility of results of photodynamic therapy (PDT) studies. Unfortunately, only few illumination devices dedicated to preclinical studies are available and are for the most, very expensive. Mostresearch teams use home-made solutions that may not always be reproducible because of undefined light distribution, additive thermal emission, or unsuitable for shapes and volumes to illuminate. To address these issues, we developed illumination devices dedicated to our preclinical studies, which embed knitted light emitting fabrics (LEF) technology. LEF technology offers a homogeneous light distribution, without thermal emission and can be coupled with various light sources allowinginvestigation of several PDT modalities (irradiance, wavelength, illumination duration/mode). For in-vitro studies, we designed light plates,each allowing illumination of up to four 96-cells plates. For in-vivo studies, we designed mice boxes allowing three animals placement in prone position, equally surrounded by LEF and ensuring homogeneous extracorporeal illumination. Optical validation was performed and reproducibility of both preclinical systems were assessed. Both systems can deliver homogeneous light with an irradiance that can reachseveral mW/cm 2 , with varying durations and wavelengths. First results of preclinical studies demonstrate a high reproducibility, with an easy setup, and a great adaptability of illumination modalities with these devices based on light emitting fabrics.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL

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