Control of Cell Identity by the Nuclear ...
Document type :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Title :
Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology
Author(s) :
Dubois, Vanessa [Auteur correspondant]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Lefebvre, Philippe [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Verzi, Michael [Auteur]
Rutgers University [Camden]
Eeckhoute, Jérôme [Auteur correspondant]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Lefebvre, Philippe [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Verzi, Michael [Auteur]
Rutgers University [Camden]
Eeckhoute, Jérôme [Auteur correspondant]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Journal title :
Cells
Pages :
2185
Publisher :
MDPI
Publication date :
2020-09-28
ISSN :
2073-4409
English keyword(s) :
HNF4 nuclear receptor
cell identity
functional genomics
liver and gastrointestinal pathophysiology
cell identity
functional genomics
liver and gastrointestinal pathophysiology
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal ...
Show more >Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of cellular differentiation during development and a safekeeper of acquired cell identity in adult organs. Importantly, we discuss that transient loss of HNF4 may represent a protective mechanism upon acute organ injury, while prolonged impairment of HNF4 activities could contribute to organ dysfunction. In this context, we describe in detail mechanisms involved in the pathophysiological control of cell identity by HNF4, including how HNF4 works as part of cell-specific TF networks and how its expression/activities are disrupted in injured organs.Show less >
Show more >Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of cellular differentiation during development and a safekeeper of acquired cell identity in adult organs. Importantly, we discuss that transient loss of HNF4 may represent a protective mechanism upon acute organ injury, while prolonged impairment of HNF4 activities could contribute to organ dysfunction. In this context, we describe in detail mechanisms involved in the pathophysiological control of cell identity by HNF4, including how HNF4 works as part of cell-specific TF networks and how its expression/activities are disrupted in injured organs.Show less >
Language :
Anglais
Popular science :
Non
ANR Project :
Source :
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