Five-year outcomes following timely primary ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
Five-year outcomes following timely primary percutaneous intervention, late primary percutaneous intervention, or a pharmaco-invasive strategy in ST-segment elevation myocardial infarction: the FAST-MI programme
Auteur(s) :
Danchin, Nicolas [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Popovic, Batric [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Puymirat, Etienne [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Goldstein, Patrick [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Belle, Loic [Auteur]
Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois]
Cayla, Guillaume [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Roubille, François [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Lemesle, Gilles [Auteur]
Institut Coeur Poumon [CHU Lille]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Faculté de Médecine Henri Warembourg - Université de Lille
Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials [FACT]
Ferrieres, Jean [Auteur]
Centre de Physiopathologie de Toulouse-Purpan [INSERM U563 - CNRS UMR1037]
Service Cardiologie [CHU Toulouse]
Schiele, Francois [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Simon, Tabassome [Auteur]
Sorbonne Université [SU]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
CHU Saint-Antoine [AP-HP]
Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] [CIC Paris-Est]
Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials [FACT]
Université Paris Descartes - Paris 5 [UPD5]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Popovic, Batric [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Puymirat, Etienne [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Goldstein, Patrick [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Belle, Loic [Auteur]
Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois]
Cayla, Guillaume [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Roubille, François [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Lemesle, Gilles [Auteur]
Institut Coeur Poumon [CHU Lille]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Faculté de Médecine Henri Warembourg - Université de Lille
Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials [FACT]
Ferrieres, Jean [Auteur]
Centre de Physiopathologie de Toulouse-Purpan [INSERM U563 - CNRS UMR1037]
Service Cardiologie [CHU Toulouse]
Schiele, Francois [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Simon, Tabassome [Auteur]
Sorbonne Université [SU]
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
CHU Saint-Antoine [AP-HP]
Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] [CIC Paris-Est]
Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials [FACT]
Titre de la revue :
European Heart Journal
Pagination :
858-866
Éditeur :
Oxford University Press (OUP)
Date de publication :
2020-02-14
ISSN :
0195-668X
Mot(s)-clé(s) en anglais :
Timing
Acute myocardial infarction
Fibrinolysis
Long-term outcome
Primary PCI
Acute myocardial infarction
Fibrinolysis
Long-term outcome
Primary PCI
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Résumé en anglais : [en]
AIMS : ST-segment elevation myocardial infarction (STEMI) guidelines recommend primary percutaneous coronary intervention (pPCI) as the default reperfusion strategy when feasible ≤120 min of diagnostic ECG, and a ...
Lire la suite >AIMS : ST-segment elevation myocardial infarction (STEMI) guidelines recommend primary percutaneous coronary intervention (pPCI) as the default reperfusion strategy when feasible ≤120 min of diagnostic ECG, and a pharmaco-invasive strategy otherwise. There is, however, a lack of direct evidence to support the guidelines, and in real-world situations, pPCI is often performed beyond recommended timelines. To assess 5-year outcomes according to timing of pPCI (timely vs. late) compared with a pharmaco-invasive strategy (fibrinolysis with referral to PCI centre).METHODS AND RESULTS : The French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) programme consists of nationwide observational surveys consecutively recruiting patients admitted for acute myocardial infarction every 5 years. Among the 4250 STEMI patients in the 2005 and 2010 cohorts, those with reperfusion therapy and onset-to-first call time <12 h (n = 2942) were included. Outcomes at 5 years were compared according to type of reperfusion strategy and timing of pPCI, using Cox multivariable analyses and propensity score matching. Among those, 1288 (54%) patients had timely pPCI (≤120 min from ECG), 830 (28%) late pPCI (>120 min), and 824 (28%) intravenous fibrinolysis. Five-year survival was higher with a pharmaco-invasive strategy (89.8%) compared with late pPCI [79.5%; adjusted hazard ratio (HR) 1.51; 1.13-2.02] and similar to timely pPCI (88.2%, adjusted HR 1.02; 0.75-1.38). Concordant results were observed in propensity score-matched cohorts and for event-free survival.CONCLUSION : A substantial proportion of patients have pPCI beyond recommended timelines. As foreseen by the guidelines, these patients have poorer 5-year outcomes, compared with a pharmaco-invasive strategy.Lire moins >
Lire la suite >AIMS : ST-segment elevation myocardial infarction (STEMI) guidelines recommend primary percutaneous coronary intervention (pPCI) as the default reperfusion strategy when feasible ≤120 min of diagnostic ECG, and a pharmaco-invasive strategy otherwise. There is, however, a lack of direct evidence to support the guidelines, and in real-world situations, pPCI is often performed beyond recommended timelines. To assess 5-year outcomes according to timing of pPCI (timely vs. late) compared with a pharmaco-invasive strategy (fibrinolysis with referral to PCI centre).METHODS AND RESULTS : The French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) programme consists of nationwide observational surveys consecutively recruiting patients admitted for acute myocardial infarction every 5 years. Among the 4250 STEMI patients in the 2005 and 2010 cohorts, those with reperfusion therapy and onset-to-first call time <12 h (n = 2942) were included. Outcomes at 5 years were compared according to type of reperfusion strategy and timing of pPCI, using Cox multivariable analyses and propensity score matching. Among those, 1288 (54%) patients had timely pPCI (≤120 min from ECG), 830 (28%) late pPCI (>120 min), and 824 (28%) intravenous fibrinolysis. Five-year survival was higher with a pharmaco-invasive strategy (89.8%) compared with late pPCI [79.5%; adjusted hazard ratio (HR) 1.51; 1.13-2.02] and similar to timely pPCI (88.2%, adjusted HR 1.02; 0.75-1.38). Concordant results were observed in propensity score-matched cohorts and for event-free survival.CONCLUSION : A substantial proportion of patients have pPCI beyond recommended timelines. As foreseen by the guidelines, these patients have poorer 5-year outcomes, compared with a pharmaco-invasive strategy.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :