Liver-specific RORα deletion does not ...
Document type :
Compte-rendu et recension critique d'ouvrage
PMID :
Title :
Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding
Author(s) :
Molinaro, Antonio [Auteur]
Caesar, Robert [Auteur]
L'Homme, Laurent [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Koh, Ara [Auteur]
Ståhlman, Marcus [Auteur]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Bäckhed, Fredrik [Auteur correspondant]
Novo Nordisk Foundation Center for Basic Metabolic Research [CBMR]
Caesar, Robert [Auteur]
L'Homme, Laurent [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Koh, Ara [Auteur]
Ståhlman, Marcus [Auteur]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Bäckhed, Fredrik [Auteur correspondant]
Novo Nordisk Foundation Center for Basic Metabolic Research [CBMR]
Journal title :
Molecular metabolism
Pages :
82-87
Publisher :
Elsevier
Publication date :
2019-05
ISSN :
2212-8778
English keyword(s) :
Obesity
Glucose metabolism
Steatosis
RORα
RORa
Glucose metabolism
Steatosis
RORα
RORa
HAL domain(s) :
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
English abstract : [en]
The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) ...
Show more >The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic RORα by generating mice with liver-specific RORα deletion to elucidate the role of this nuclear receptor on host metabolism.Show less >
Show more >The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an important nuclear receptor involved in several biological processes. RORα full body knockout mice display improved metabolic phenotypes on both chow and high fat (60% fat, 20% carbohydrate) diets, but also have severe behavioral abnormalities. Here we investigated the effect of hepatic RORα by generating mice with liver-specific RORα deletion to elucidate the role of this nuclear receptor on host metabolism.Show less >
Language :
Anglais
Popular science :
Non
European Project :
Source :
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