Anxiety in Parkinson's disease is associated ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Anxiety in Parkinson's disease is associated with changes in the brain fear circuit
Author(s) :
Carey, Guillaume [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lopes, Renaud [Auteur]
Viard, Romain [Auteur]
Betrouni, Nacim [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Kuchcinski, Gregory [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Devignes, Quentin [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
DEFEBVRE, Luc [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Leentjens, Albert F.G. [Auteur]
Maastricht University [Maastricht]
Dujardin, Kathy [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lopes, Renaud [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Viard, Romain [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Betrouni, Nacim [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Lille Neurosciences & Cognition (LilNCog) - U 1172
Kuchcinski, Gregory [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Devignes, Quentin [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
DEFEBVRE, Luc [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Lille Neurosciences & Cognition (LilNCog) - U 1172
Leentjens, Albert F.G. [Auteur]
Maastricht University [Maastricht]
Dujardin, Kathy [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Lille Neurosciences & Cognition (LilNCog) - U 1172
Journal title :
Parkinsonism & Related Disorders
Abbreviated title :
Parkinsonism & Related Disorders
Pages :
89-97
Publisher :
Elsevier BV
Publication date :
2020-11-01
ISSN :
1353-8020
HAL domain(s) :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentale
English abstract : [en]
Background: Anxiety is frequent in Parkinson's disease (PD) and has a negative impact on disease symptoms and quality of life. The underlying mechanisms remain largely unknown. The aim of this study was to identify anatomical ...
Show more >Background: Anxiety is frequent in Parkinson's disease (PD) and has a negative impact on disease symptoms and quality of life. The underlying mechanisms remain largely unknown. The aim of this study was to identify anatomical and functional changes associated to PD-related anxiety by comparing the volume, shape and texture of the amygdala, the cortical thickness as well as the functional connectivity (FC) of the fear circuit in patients with and without clinically relevant anxiety. Methods: Non-demented PD patients were recruited, and anxiety was quantified using the Parkinson Anxiety Scale. Structural MRI was used to compare cortical thickness and amygdala structure and resting-state functional MRI to compare FC patterns of the amygdala and resting-state functional networks in both groups. Results: We included 118 patients: 34 with (A+) and 84 without (A-) clinically relevant anxiety. Clusters of cortical thinning were identified in the bilateral fronto-cingulate and left parietal cortices of the A+ group. The texture and the shape of the left amygdala was different in the A+ group but the overall volume did not differ between groups. FC between the amygdala and the whole brain regions did not differ between groups. The internetwork resting-state FC was higher between the "fear circuit" and salience network in the A+ group. Conclusion: Anxiety in PD induces structural modifications of the left amygdala, atrophy of the bilateral fronto-cingulate and the left parietal cortices, and a higher internetwork resting-state FC between the fear circuit and the salience network.Show less >
Show more >Background: Anxiety is frequent in Parkinson's disease (PD) and has a negative impact on disease symptoms and quality of life. The underlying mechanisms remain largely unknown. The aim of this study was to identify anatomical and functional changes associated to PD-related anxiety by comparing the volume, shape and texture of the amygdala, the cortical thickness as well as the functional connectivity (FC) of the fear circuit in patients with and without clinically relevant anxiety. Methods: Non-demented PD patients were recruited, and anxiety was quantified using the Parkinson Anxiety Scale. Structural MRI was used to compare cortical thickness and amygdala structure and resting-state functional MRI to compare FC patterns of the amygdala and resting-state functional networks in both groups. Results: We included 118 patients: 34 with (A+) and 84 without (A-) clinically relevant anxiety. Clusters of cortical thinning were identified in the bilateral fronto-cingulate and left parietal cortices of the A+ group. The texture and the shape of the left amygdala was different in the A+ group but the overall volume did not differ between groups. FC between the amygdala and the whole brain regions did not differ between groups. The internetwork resting-state FC was higher between the "fear circuit" and salience network in the A+ group. Conclusion: Anxiety in PD induces structural modifications of the left amygdala, atrophy of the bilateral fronto-cingulate and the left parietal cortices, and a higher internetwork resting-state FC between the fear circuit and the salience network.Show less >
Peer reviewed article :
Oui
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2021-03-16T09:31:21Z
2021-03-30T14:32:55Z
2021-03-30T14:32:55Z
Files
- PRD-AnxPD-GC.pdf
- Version finale acceptée pour publication (postprint)
- Open access
- Access the document