Genetic underpinnings in Alzheimer's disease ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Genetic underpinnings in Alzheimer's disease - a review
Author(s) :
Moustafa, Ahmed A. [Auteur]
Hassan, Mubashir [Auteur]
Hewedi, Doaa H. [Auteur]
Hewedi, Iman [Auteur]
Garami, Julia K. [Auteur]
Al Ashwal, Hany [Auteur]
Zaki, Nazar [Auteur]
Seo, Sung-Yum [Auteur]
Cutsuridis, Vassilis [Auteur]
Angulo, Sergio L. [Auteur]
Natesh, Joman Y. [Auteur]
Herzallah, Mohammad M. [Auteur]
Frydecka, Dorota [Auteur]
Misiak, Błażej [Auteur]
Salama, Mohamed [Auteur]
Mohamed, Wael [Auteur]
El Haj, Mohamad [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Hornberger, Michael [Auteur]
Hassan, Mubashir [Auteur]
Hewedi, Doaa H. [Auteur]
Hewedi, Iman [Auteur]
Garami, Julia K. [Auteur]
Al Ashwal, Hany [Auteur]
Zaki, Nazar [Auteur]
Seo, Sung-Yum [Auteur]
Cutsuridis, Vassilis [Auteur]
Angulo, Sergio L. [Auteur]
Natesh, Joman Y. [Auteur]
Herzallah, Mohammad M. [Auteur]
Frydecka, Dorota [Auteur]
Misiak, Błażej [Auteur]
Salama, Mohamed [Auteur]
Mohamed, Wael [Auteur]
El Haj, Mohamad [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Hornberger, Michael [Auteur]
Journal title :
Reviews in the Neurosciences
Abbreviated title :
Rev Neurosci
Volume number :
29
Pages :
21-38
Publication date :
2017-09-26
ISSN :
0334-1763
HAL domain(s) :
Sciences cognitives
English abstract : [en]
In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the ...
Show more >In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.Show less >
Show more >In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Submission date :
2019-02-13T14:17:46Z
2020-02-06T08:41:32Z
2020-02-06T08:41:32Z