Hyposialylation Must Be Considered to ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases
Auteur(s) :
Bordron, Anne [Auteur]
Morel, Marie [Auteur]
Bagacean, Cristina [Auteur]
Dueymes, Maryvonne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pochard, Pierre [Auteur]
Harduin Lepers, Anne [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Jamin, Christophe [Auteur]
Pers, Jacques-Olivier [Auteur]
Morel, Marie [Auteur]
Bagacean, Cristina [Auteur]
Dueymes, Maryvonne [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Pochard, Pierre [Auteur]
Harduin Lepers, Anne [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Jamin, Christophe [Auteur]
Pers, Jacques-Olivier [Auteur]
Titre de la revue :
International journal of molecular sciences
Nom court de la revue :
IJMS
Numéro :
22
Pagination :
3402
Éditeur :
MDPI AG
Date de publication :
2021-03-26
ISSN :
1422-0067
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the ...
Lire la suite >Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the terminal end of glycoproteins and glycolipids is essential for distinguishing between self and non-self-antigens and the control of pro- or anti-inflammatory immune reactions. In autoimmunity, hyposialylation is responsible for chronic inflammation, the anarchic activation of the immune system and organ lesions. A detailed characterization of this mechanism is a key element for improving the understanding of these diseases and the development of innovative therapies. This review focuses on the impact of sialylation in autoimmunity in order to determine future treatments based on the regulation of hyposialylation.Lire moins >
Lire la suite >Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the terminal end of glycoproteins and glycolipids is essential for distinguishing between self and non-self-antigens and the control of pro- or anti-inflammatory immune reactions. In autoimmunity, hyposialylation is responsible for chronic inflammation, the anarchic activation of the immune system and organ lesions. A detailed characterization of this mechanism is a key element for improving the understanding of these diseases and the development of innovative therapies. This review focuses on the impact of sialylation in autoimmunity in order to determine future treatments based on the regulation of hyposialylation.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
CNRS
Collections :
Équipe(s) de recherche :
Régulation de la glycosylation terminale
Date de dépôt :
2021-06-21T10:08:58Z
Fichiers
- P21.01 Bordron et al ijms 2021 review sialyltion auto immune diseases.pdf
- Version éditeur
- Accès libre
- Accéder au document