Promising Drug Candidates and New Strategies ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris
Auteur(s) :
Billamboz, Muriel [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Fatima, Zeeshan [Auteur]
Hameed, Saif [Auteur]
Jawhara, Samir [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Fatima, Zeeshan [Auteur]
Hameed, Saif [Auteur]
Jawhara, Samir [Auteur]
Titre de la revue :
Microorganisms
Nom court de la revue :
Microorganisms
Numéro :
9
Pagination :
634
Éditeur :
MDPI AG
Date de publication :
2021-03-18
ISSN :
2076-2607
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the ...
Lire la suite >Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of C. auris. We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging C. auris pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies.Lire moins >
Lire la suite >Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of C. auris. We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging C. auris pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
CNRS
Collections :
Date de dépôt :
2021-06-22T12:06:09Z
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- P21.12 microorganisms-09-00634-v3.pdf
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