Fkbp5 gene variants and borderline personality disorder

Amad, Ali; Ramoz, Nicolas; Peyre, Hugo; Thomas, Pierre; Gorwood, Philip

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.jad.2019.01.025

PMID :

30711865

Permalink :

http://hdl.handle.net/20.500.12210/40033

Title :

Fkbp5 gene variants and borderline personality disorder

Author(s) :

Amad, Ali [Auteur]

415060|||Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Ramoz, Nicolas [Auteur]
Peyre, Hugo [Auteur]
Thomas, Pierre [Auteur]

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Gorwood, Philip [Auteur]

Journal title :

Journal of affective disorders

Abbreviated title :

J Affect Disord

Volume number :

248

Pages :

26-28

Publication date :

2019-01-27

ISSN :

1573-2517

Keyword(s) :

Borderline personality disorder
FKBP5
SNP
Stress axis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD). Methods In ...
Show more >Background Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD). Methods In this study, five FKBP5 (a co-chaperone of the glucocorticoid receptor) SNPs (rs3800373, rs9296158, rs737054, rs1360780, rs9470080) were genotyped in a sample of 101 unrelated Caucasian patients with BPD and 111 ethnically matched healthy controls. The interaction between FKBP5 polymorphisms and childhood trauma was also tested. Results All FKBP5 polymorphisms genotyped showed significant associations with BPD. A main effect of rs9470080 (p = 0.01) and gene x environment (physical abuse) interaction (p = 0.01) was found. A gene x environment (emotional abuse) interaction was also found for rs3800373 (p = 0.03). However, these interactions did not remain significant after multiple testing corrections. Limitations In this study, only 5 genetic variants were tested and thus tagging of the FKBP5 gene was incomplete. Moreover, the sample size is moderate. Conclusion BPD is associated with FKBP5 polymorphisms and several types of childhood abuse may modulate the effect between FKBP5 SNPs and this disorder.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Submission date :

2021-06-23T13:41:12Z
2023-06-05T14:36:06Z

Version	Link	Modification date
2	20.500.12210/40033*	2023-06-05T14:34:58Z
1	20.500.12210/40033.1	2021-06-23T13:41:12Z

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