Effects of Methylphenidate on Default-Mode ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
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Title :
Effects of Methylphenidate on Default-Mode Network/Task-Positive Network Synchronization in Children With ADHD
Author(s) :
Querne, Laurent [Auteur]
Fall, Sidy [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
Bourel-Ponchel, Emilie [Auteur]
Delignières, Aline [Auteur]
Simonnot, Anais [Auteur]
de Broca, Alain [Auteur]
Gondry-Jouet, Catherine [Auteur]
Boucart, Muriel [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Berquin, Patrick [Auteur]
Berquin, Patrick [Auteur]
Fall, Sidy [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
Bourel-Ponchel, Emilie [Auteur]
Delignières, Aline [Auteur]
Simonnot, Anais [Auteur]
de Broca, Alain [Auteur]
Gondry-Jouet, Catherine [Auteur]
Boucart, Muriel [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Berquin, Patrick [Auteur]
Berquin, Patrick [Auteur]
Journal title :
Journal of Attention Disorders
Abbreviated title :
J Atten Disord
Volume number :
21
Pages :
1208-1220
Publication date :
2017-12
ISSN :
1557-1246
HAL domain(s) :
Sciences cognitives
English abstract : [en]
OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby ...
Show more >OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby methylphenidate may improve TPN/DMN synchronization in ADHD. METHOD: Eleven drug-naive ADHD children and 11 typically developing (TD) children performed a flanker task during functional magnetic resonance imaging. The ADHD group was scanned without and 1 month later with methylphenidate. The signal was analyzed by independent component analysis. RESULTS: The TD group showed anti-phase DMN/TPN synchronization. The unmedicated ADHD group showed synchronous activity in the posterior DMN only, which was positively correlated with response time variability for the flanker task. Methylphenidate initiated a partial anti-phase TPN/DMN synchronization, reduced variability, and abolished the variability/DMN correlation. CONCLUSION: Although results should be interpreted cautiously because the sample size is small, they suggest that a failure of the TPN/DMN synchronization could be involved in the moment-to-moment variability in ADHD. Methylphenidate initiated TPN/DMN synchronization, which in turn appeared to reduce variability.Show less >
Show more >OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby methylphenidate may improve TPN/DMN synchronization in ADHD. METHOD: Eleven drug-naive ADHD children and 11 typically developing (TD) children performed a flanker task during functional magnetic resonance imaging. The ADHD group was scanned without and 1 month later with methylphenidate. The signal was analyzed by independent component analysis. RESULTS: The TD group showed anti-phase DMN/TPN synchronization. The unmedicated ADHD group showed synchronous activity in the posterior DMN only, which was positively correlated with response time variability for the flanker task. Methylphenidate initiated a partial anti-phase TPN/DMN synchronization, reduced variability, and abolished the variability/DMN correlation. CONCLUSION: Although results should be interpreted cautiously because the sample size is small, they suggest that a failure of the TPN/DMN synchronization could be involved in the moment-to-moment variability in ADHD. Methylphenidate initiated TPN/DMN synchronization, which in turn appeared to reduce variability.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Research team(s) :
Équipe Action, Vision et Apprentissage (AVA)
Submission date :
2019-02-13T14:18:02Z
2019-11-08T10:57:30Z
2019-11-08T10:57:30Z