Effects of Methylphenidate on Default-Mode ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Effects of Methylphenidate on Default-Mode Network/Task-Positive Network Synchronization in Children With ADHD
Auteur(s) :
Querne, Laurent [Auteur]
Fall, Sidy [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
Bourel-Ponchel, Emilie [Auteur]
Delignières, Aline [Auteur]
Simonnot, Anais [Auteur]
de Broca, Alain [Auteur]
Gondry-Jouet, Catherine [Auteur]
Boucart, Muriel [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Berquin, Patrick [Auteur]
Berquin, Patrick [Auteur]
Fall, Sidy [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
Bourel-Ponchel, Emilie [Auteur]
Delignières, Aline [Auteur]
Simonnot, Anais [Auteur]
de Broca, Alain [Auteur]
Gondry-Jouet, Catherine [Auteur]
Boucart, Muriel [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Berquin, Patrick [Auteur]
Berquin, Patrick [Auteur]
Titre de la revue :
Journal of Attention Disorders
Nom court de la revue :
J Atten Disord
Numéro :
21
Pagination :
1208-1220
Date de publication :
2017-12
ISSN :
1557-1246
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby ...
Lire la suite >OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby methylphenidate may improve TPN/DMN synchronization in ADHD. METHOD: Eleven drug-naive ADHD children and 11 typically developing (TD) children performed a flanker task during functional magnetic resonance imaging. The ADHD group was scanned without and 1 month later with methylphenidate. The signal was analyzed by independent component analysis. RESULTS: The TD group showed anti-phase DMN/TPN synchronization. The unmedicated ADHD group showed synchronous activity in the posterior DMN only, which was positively correlated with response time variability for the flanker task. Methylphenidate initiated a partial anti-phase TPN/DMN synchronization, reduced variability, and abolished the variability/DMN correlation. CONCLUSION: Although results should be interpreted cautiously because the sample size is small, they suggest that a failure of the TPN/DMN synchronization could be involved in the moment-to-moment variability in ADHD. Methylphenidate initiated TPN/DMN synchronization, which in turn appeared to reduce variability.Lire moins >
Lire la suite >OBJECTIVE: A failure of the anti-phase synchronization between default-mode (DMN) and task-positive networks (TPN) may be involved in a main manifestation of ADHD: moment-to-moment variability. The study investigated whereby methylphenidate may improve TPN/DMN synchronization in ADHD. METHOD: Eleven drug-naive ADHD children and 11 typically developing (TD) children performed a flanker task during functional magnetic resonance imaging. The ADHD group was scanned without and 1 month later with methylphenidate. The signal was analyzed by independent component analysis. RESULTS: The TD group showed anti-phase DMN/TPN synchronization. The unmedicated ADHD group showed synchronous activity in the posterior DMN only, which was positively correlated with response time variability for the flanker task. Methylphenidate initiated a partial anti-phase TPN/DMN synchronization, reduced variability, and abolished the variability/DMN correlation. CONCLUSION: Although results should be interpreted cautiously because the sample size is small, they suggest that a failure of the TPN/DMN synchronization could be involved in the moment-to-moment variability in ADHD. Methylphenidate initiated TPN/DMN synchronization, which in turn appeared to reduce variability.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Équipe(s) de recherche :
Équipe Action, Vision et Apprentissage (AVA)
Date de dépôt :
2019-02-13T14:18:02Z
2019-11-08T10:57:30Z
2019-11-08T10:57:30Z