Titre :

Long-term mortality in survivors of spontaneous intracerebral hemorrhage

Auteur(s) :

Pasi, Marco [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Casolla, Barbara [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Kyheng, Maéva [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Boulouis, Gregoire [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Kuchcinski, Gregory [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Labreuche, Julien [Auteur]
Santé Publique : épidémiologie et qualité des soins [EA 2694]
Henon, Hilde [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Leys, Didier [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Titre de la revue :

International journal of stroke . official journal of the International Stroke Society

Nom court de la revue :

Int J Stroke

Numéro :

16

Pagination :

1747493020954946

Éditeur :

SAGE Journals

Date de publication :

2020-09-03

ISSN :

1747-4949

Mot(s)-clé(s) :

cerebral atrophy
cerebral small-vessel disease
long-term outcome
mortality
stroke
Intracerebral hemorrhage

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Background Factors associated with long-term mortality after spontaneous intracerebral hemorrhage (ICH) have been poorly investigated. Aim Our objective was to identify variables associated with long-term mortality in ...
Lire la suite >Background Factors associated with long-term mortality after spontaneous intracerebral hemorrhage (ICH) have been poorly investigated. Aim Our objective was to identify variables associated with long-term mortality in a prospective cohort of 30-day ICH survivors. Methods We prospectively included consecutive 30-day spontaneous ICH survivors. We evaluated baseline and follow-up clinical characteristics and magnetic resonance imaging (MRI) markers of chronic brain injury as variables associated with long-term mortality using univariate and multivariable Cox proportional hazard regression models. Results Of 560 patients with spontaneous ICH, 304 (54.2%) survived more than 30 days and consented for follow-up. During a median follow-up of 10 years (interquartile range: 8.0–10.5), 176 patients died. The cumulative survival rate at 10 years was 38%. In multivariable analysis, variables independently associated with long-term mortality were age (hazard ratio (HR) per 10-year increase: 1.68, 95% confidence interval (CI): 1.45–1.95), male gender (HR: 1.41, CI: 1.02–1.95), prestroke dependency (HR: 1.66, CI: 1.15–2.39), National Institutes of Health Stroke Scale score (HR per 1-point increase: 1.03, CI: 1.01–1.04), occurrence of any stroke (HR: 2.24, CI: 1.39–3.60), and dementia (HR: 1.51, CI: 1.06–2.16) during follow-up. Among MRI markers, only cerebral atrophy (HR per 1-point increase: 1.50, CI: 1.13–2.00) was independently associated with long-term mortality. Conclusions Preexisting comorbidities, clinical severity at presentation, and significant clinical event during follow-up are associated with long-term mortality. Among MRI markers of chronic brain injury, only cerebral atrophy is associated with long-term mortality.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2021-06-23T13:47:50Z
2024-03-27T08:57:39Z