Title :

Transcranial direct-current stimulation (tDCS) for bipolar depression: A systematic review and meta-analysis

Author(s) :

Dondé, Clément [Auteur]
Amad, Ali [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Nieto, Isabel [Auteur]
Fondation FondaMental [Créteil]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Brunoni, André Russowsky [Auteur]

Neufeld, Nicholas H. [Auteur]
University of Toronto
Bellivier, Frank [Auteur]
Fondation FondaMental [Créteil]
Variabilité de réponse aux Psychotropes [VariaPsy - U1144]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Poulet, Emmanuel [Auteur]
Centre Hospitalier le Vinatier [Bron]
Geoffroy, Pierre-Alexis [Auteur]
Fondation FondaMental [Créteil]
Variabilité de réponse aux Psychotropes [VariaPsy - U1144]
Hopital Saint-Louis [AP-HP] [AP-HP]

Journal title :

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Abbreviated title :

Prog. Neuropsychopharmacol. Biol. Psychiatry

Volume number :

78

Pages :

123-131

Publication date :

2017-08-01

ISSN :

1878-4216

English keyword(s) :

Bipolar disorder
Mood disorder
Depression
Transcranial direct current stimulation
Side effects

HAL domain(s) :

Sciences cognitives

English abstract : [en]

OBJECTIVE: Bipolar disorder (BD) is a severe and recurrent brain disorder that can manifest in manic or depressive episodes. Transcranial Direct Current Stimulation (tDCS) has been proposed as a novel therapeutic modality ...
Show more >OBJECTIVE: Bipolar disorder (BD) is a severe and recurrent brain disorder that can manifest in manic or depressive episodes. Transcranial Direct Current Stimulation (tDCS) has been proposed as a novel therapeutic modality for patients experiencing bipolar depression, for which standard treatments are often inefficient. While several studies have been conducted in this patient group, there has been no systematic review or meta-analysis that specifically examines bipolar depression. We aimed to address this gap in the literature and evaluated the efficacy and tolerability of tDCS in patients fulfilling DSM-IV-TR criteria for BD I, II, or BD not otherwise specified (NOS). METHODS: We systematically searched the literature from April 2002 to November 2016 to identify relevant publications for inclusion in our systematic review and meta-analysis. Effect sizes for depression rating-scale scores were expressed as the standardized mean difference (SMD) before and after tDCS. RESULTS: Thirteen of 382 identified studies met eligibility criteria for our systematic review. The meta-analysis included 46 patients from 7 studies with depression rating-scale scores pre- and post-tDCS. Parameters of tDCS procedures were heterogeneous. Depression scores decreased significantly with a medium effect size after acute-phase of treatment (SMD 0.71 [0.25-1.18], z=3.00, p=0.003) and at the furthest endpoint (SMD 1.27 [0.57-1.97], z=3.57, p=0.0004). Six cases of affective switching under tDCS treatment protocols were observed. CONCLUSIONS: Depressive symptoms respond to tDCS in patients with BD. Additional studies, and particularly randomized controlled trials, are needed to clarify the effectiveness of tDCS in bipolar depression, the frequency of tDCS-emergent hypomania/mania, and which tDCS modalities are most efficient.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Research team(s) :

Équipe Psychiatrie & Croyance (PsyCHIC)

Submission date :

2019-02-13T14:21:38Z
2020-04-20T08:39:11Z