Title :

Association between acute graft pyelonephritis and kidney graft survival: a single-center observational study

Author(s) :

Maanaoui, Mehdi [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Baes, Dulciane [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Hamroun, Aghiles [Auteur]
Centre de recherche en épidémiologie et santé des populations [CESP]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Khedjat, Kahina [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Vuotto, Fanny [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Faure, Emmanuel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lopez, Benjamin [Auteur]
Bouye, Sebastien [Auteur]
Service d'Urologie, andrologie et transplantation rénale [CHRU Lille]
Caes, Thomas [Auteur]
Service d'Urologie, andrologie et transplantation rénale [CHRU Lille]
Lionet, Arnaud [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Lebas, Celine [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Provot, Francois [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Glowacki, Francois [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Gibier, Jean-Baptiste [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172
Lenain, Remi [Auteur]
Service de Néphrologie et Transplantation rénale [CHRU-lille]
Hazzan, Marc [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Service de Néphrologie et Transplantation rénale [CHRU-lille]

Journal title :

American Journal of Transplantation

Abbreviated title :

Am J Transplant

Publication date :

2021-05-31

ISSN :

1600-6143

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The association between acute graft pyelonephritis (AGPN) and graft failure in kidney transplant recipients (KTR) remains controversial. In this single-center observational study, we aimed to assess the incidence of AGPN ...
Show more >The association between acute graft pyelonephritis (AGPN) and graft failure in kidney transplant recipients (KTR) remains controversial. In this single-center observational study, we aimed to assess the incidence of AGPN as a time-dependent posttransplantation event. We also examined the association between the diagnosis of AGPN and graft outcomes. In total, we evaluated 1480 patients who underwent kidney transplantation between January 2007 and December 2017. During a median follow-up of 5.04 years, we observed 297 AGPN episodes that occurred in 158 KTR. To evaluate the association between AGPN and clinical outcomes, we performed Cox proportional hazards regression analyses in which AGPN was entered as a time-dependent covariate. AGPN was independently associated with an increased risk of graft loss (hazard ratio = 1.66; 95% confidence interval [CI]: 1.05–2.64, p < .03) and a persistently decreased eGFR (fixed effect on intercept: –2.29 ml/min/1.73 m2; 95% CI: from –3.23 to –1.35, p < .01). However, neither mortality nor biopsy-proven acute rejection was found to correlate with AGPN. Moreover, recurrent AGPN episodes did not appear to have an additive detrimental impact on graft loss. These data represent a promising step in understanding whether AGPN prevention may decrease the risk of graft loss in KTR.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:44:14Z
2024-02-05T13:25:08Z