Intestinal virome in patients with alcoholic ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Intestinal virome in patients with alcoholic hepatitis
Auteur(s) :
Jiang, Lu [Auteur]
University of California [San Diego] [UC San Diego]
Lang, Sonja [Auteur]
University of California [San Diego] [UC San Diego]
Duan, Yi [Auteur]
University of California [San Diego] [UC San Diego]
Zhang, Xinlian [Auteur]
University of California [San Diego] [UC San Diego]
Gao, Bei [Auteur]
University of California [San Diego] [UC San Diego]
Chopyk, Jessica [Auteur]
University of California [San Diego] [UC San Diego]
Schwanemann, Leila K. [Auteur]
University of California [San Diego] [UC San Diego]
Ventura-Cots, Meritxell [Auteur]
University of Pittsburgh [PITT]
Bataller, Ramon [Auteur]
University of Pittsburgh [PITT]
Bosques-Padilla, Francisco [Auteur]
California State University [Monterey Bay] [CSUMB]
Verna, Elizabeth C. [Auteur]
Columbia University College of Physicians and Surgeons
Abraldes, Juan G. [Auteur]
University of Alberta
Brown, Robert S. [Auteur]
Weill Medical College of Cornell University [New York]
Vargas, Victor [Auteur]
Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas [CIBERehd]
University of Barcelona
Altamirano, Jose [Auteur]
University of Barcelona
Caballeria, Juan [Auteur]
Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas [CIBERehd]
Clinic Barcelona Hospital Universitari
Shawcross, Debbie L. [Auteur]
King‘s College London
Ho, Samuel B. [Auteur]
University of California [San Diego] [UC San Diego]
Louvet, Alexandre [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lucey, Michael R. [Auteur]
University of Wisconsin School of Medicine and Public Health
Mathurin, Philippe [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Garcia-Tsao, Guadalupe [Auteur]
Yale University [New Haven]
Kisseleva, Tatiana [Auteur]
University of California [San Diego] [UC San Diego]
Brenner, David A. [Auteur]
University of California [San Diego] [UC San Diego]
Tu, Xin M. [Auteur]
University of California [San Diego] [UC San Diego]
Starkel, Peter [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Pride, David [Auteur]
University of California [San Diego] [UC San Diego]
Fouts, Derrick E. [Auteur]
J. Craig Venter Institute
Schnabl, Bernd [Auteur]
University of California [San Diego] [UC San Diego]
University of California [San Diego] [UC San Diego]
Lang, Sonja [Auteur]
University of California [San Diego] [UC San Diego]
Duan, Yi [Auteur]
University of California [San Diego] [UC San Diego]
Zhang, Xinlian [Auteur]
University of California [San Diego] [UC San Diego]
Gao, Bei [Auteur]
University of California [San Diego] [UC San Diego]
Chopyk, Jessica [Auteur]
University of California [San Diego] [UC San Diego]
Schwanemann, Leila K. [Auteur]
University of California [San Diego] [UC San Diego]
Ventura-Cots, Meritxell [Auteur]
University of Pittsburgh [PITT]
Bataller, Ramon [Auteur]
University of Pittsburgh [PITT]
Bosques-Padilla, Francisco [Auteur]
California State University [Monterey Bay] [CSUMB]
Verna, Elizabeth C. [Auteur]
Columbia University College of Physicians and Surgeons
Abraldes, Juan G. [Auteur]
University of Alberta
Brown, Robert S. [Auteur]
Weill Medical College of Cornell University [New York]
Vargas, Victor [Auteur]
Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas [CIBERehd]
University of Barcelona
Altamirano, Jose [Auteur]
University of Barcelona
Caballeria, Juan [Auteur]
Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas [CIBERehd]
Clinic Barcelona Hospital Universitari
Shawcross, Debbie L. [Auteur]
King‘s College London
Ho, Samuel B. [Auteur]
University of California [San Diego] [UC San Diego]
Louvet, Alexandre [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lucey, Michael R. [Auteur]
University of Wisconsin School of Medicine and Public Health
Mathurin, Philippe [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Garcia-Tsao, Guadalupe [Auteur]
Yale University [New Haven]
Kisseleva, Tatiana [Auteur]
University of California [San Diego] [UC San Diego]
Brenner, David A. [Auteur]
University of California [San Diego] [UC San Diego]
Tu, Xin M. [Auteur]
University of California [San Diego] [UC San Diego]
Starkel, Peter [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Pride, David [Auteur]
University of California [San Diego] [UC San Diego]
Fouts, Derrick E. [Auteur]
J. Craig Venter Institute
Schnabl, Bernd [Auteur]
University of California [San Diego] [UC San Diego]
Titre de la revue :
Hepatology (Baltimore, Md.)
Nom court de la revue :
Hepatology
Date de publication :
2020-07-12
ISSN :
1527-3350
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate disease severity, little is known about the effects of the viral ...
Lire la suite >Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate disease severity, little is known about the effects of the viral microbiome (virome) in patients with ALD. We extracted virus-like particles from 89 patients with AH who were enrolled in a multicenter observational study, 36 with alcohol use disorder (AUD), and 17 persons without AUD (controls). Virus-like particles from fecal samples were fractionated using differential filtration techniques, and metagenomic sequencing was performed to characterize intestinal viromes. We observed an increased viral diversity in fecal samples from patients with ALD, with the most significant changes in samples from patients with AH. Escherichia-, Enterobacteria-, and Enterococcus phages were over-represented in fecal samples from patients with AH, along with significant increases in mammalian viruses such as Parvoviridae and Herpesviridae. Antibiotic treatment was associated with higher viral diversity. Specific viral taxa, such as Staphylococcus phages and Herpesviridae, were associated with increased disease severity, indicated by a higher median Model for End-Stage Liver Disease score, and associated with increased 90-day mortality. In conclusion, intestinal viral taxa are altered in fecal samples from patients with AH and associated with disease severity and mortality. Our study describes an intestinal virome signature associated with AH.Lire moins >
Lire la suite >Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate disease severity, little is known about the effects of the viral microbiome (virome) in patients with ALD. We extracted virus-like particles from 89 patients with AH who were enrolled in a multicenter observational study, 36 with alcohol use disorder (AUD), and 17 persons without AUD (controls). Virus-like particles from fecal samples were fractionated using differential filtration techniques, and metagenomic sequencing was performed to characterize intestinal viromes. We observed an increased viral diversity in fecal samples from patients with ALD, with the most significant changes in samples from patients with AH. Escherichia-, Enterobacteria-, and Enterococcus phages were over-represented in fecal samples from patients with AH, along with significant increases in mammalian viruses such as Parvoviridae and Herpesviridae. Antibiotic treatment was associated with higher viral diversity. Specific viral taxa, such as Staphylococcus phages and Herpesviridae, were associated with increased disease severity, indicated by a higher median Model for End-Stage Liver Disease score, and associated with increased 90-day mortality. In conclusion, intestinal viral taxa are altered in fecal samples from patients with AH and associated with disease severity and mortality. Our study describes an intestinal virome signature associated with AH.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2021-07-06T12:45:48Z
2024-01-30T12:53:18Z
2024-01-30T12:53:18Z